Evidence map›Paper›PMID 42453179›Full record

ArticleNeuro-oncology practice2026

Tumor boundary delineation in IDH-wildtype glioblastoma: A prospective comparative analysis of

Maria Pia Tropeano, Zefferino Rossini, Andrea Pizzi, Ettore Bresciani, Andrea Franzini, Beatrice Claudia Bono, Pierina Navarria, Elena Clerici, Matteo Simonelli, Marta Scorsetti and 2 more

Abstract read
In one paragraph

Article in Neuro-oncology practice, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Maria Pia TropeanoNeurosurgery Department, IRCCS Humanitas Research Hospital, Milan, Italy.ORCID https://orcid.org/0000-0002-4653-1232
Zefferino RossiniNeurosurgery Department, IRCCS Humanitas Research Hospital, Milan, Italy.
Andrea PizziNeurosurgery Department, IRCCS Humanitas Research Hospital, Milan, Italy.
Ettore BrescianiNeurosurgery Department, IRCCS Humanitas Research Hospital, Milan, Italy.
Andrea FranziniNeurosurgery Department, IRCCS Humanitas Research Hospital, Milan, Italy.
Beatrice Claudia BonoNeurosurgery Department, IRCCS Humanitas Research Hospital, Milan, Italy.
Pierina NavarriaRadiotherapy and Radiosurgery Department, IRCCS Humanitas Research Hospital, Milan, Italy.ORCID https://orcid.org/0000-0002-6913-1442
Elena ClericiRadiotherapy and Radiosurgery Department, IRCCS Humanitas Research Hospital, Milan, Italy.
Matteo SimonelliDepartment of Biomedical Sciences, Humanitas University, Milan, Italy.
Marta ScorsettiDepartment of Medical Oncology and Hematology, Humanitas Clinical and Research Center-IRCCS, Humanitas Cancer Center, Milan, Italy.
Letterio Salvatore PolitiDepartment of Biomedical Sciences, Humanitas University, Milan, Italy.
Federico PessinaNeurosurgery Department, IRCCS Humanitas Research Hospital, Milan, Italy.ORCID https://orcid.org/0000-0002-8717-4999

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Supramaximal resection (SUPR) in IDH-wildtype glioblastoma (GBM) aims to improve survival by extending resection beyond contrast-enhancing lesions into non-enhancing FLAIR-hyperintense regions. The role of metabolically guided resection with Methods: We performed a prospective, single-center study (2020-2024) including patients undergoing PET-guided resection for newly diagnosed, contrast-enhancing GBM. All patients received preoperative MRI and Results: In all cases, preoperative PET volume exceeded the contrast-enhancing (CE) volume. Spatial overlap between PET-based volume and FLAIR tumor volume (FLAIR-TV) was observed in 91.2% of cases, while in 8.8% the PET volume was larger. Strong correlations were found between FLAIR-TV and PET volumes ( Conclusions:

Indexed as

11C-MET PETglioblastomahigh grade gliomasMRIPETsupramaximal resection

Identifiers

PMID42453179
PMCPMC13365146

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.