Evidence map›Paper›PMID 42453170›Full record

ArticleClinical interventions in aging2026

Malnutrition, Frailty, and High Fall Risk in Older Adults: Examining Their Interactive Effects in a Cross-Sectional Study.

Honghong Wen, Heting Liang, Qingyun Mao, Shaoting Yang, Xiaoli Yuan

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Article in Clinical interventions in aging, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

5 authors.

Honghong WenDepartment of Nursing, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, People's Republic of China.
Heting LiangDepartment of Nursing, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, People's Republic of China.ORCID 0009-0007-8678-4385
Qingyun MaoFaculty of Nursing, Zunyi Medical University, Zunyi, Guizhou, People's Republic of China.
Shaoting YangFaculty of Nursing, Zunyi Medical University, Zunyi, Guizhou, People's Republic of China.ORCID 0009-0003-3055-9112
Xiaoli YuanDepartment of Nursing, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, People's Republic of China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Falls are a major public health concern for older adults, impacting health. Frailty and malnutrition are widely studied variables closely linked to fall risk. While the individual links of these factors with fall risk are known, their combined effects and quantitative relationships remain poorly understood. This study aimed to explore the interactive effects of malnutrition and frailty on fall risk among older adults. Methods: This study involved the recruitment of 13,970 older adults from 10 communities, who were assessed using the frailty score, the Mini-Nutritional Assessment Scale, and the STEADI tool. Multiplicative interactions were calculated through logistic regression. Additive interactions were evaluated using the relative excess risk (RERI), attribution ratio (AP), and synergy index (SI). Results: 24.1% of participants were identified as having high fall risk. Frailty and malnutrition each independently correlate with fall risk. Compared with participants who were non-frail and well-nourished, those with coexisting frailty and malnutrition had significantly higher odds of high fall risk (OR = 15.83, 95% CI: 11.77-21.28). A significant multiplicative interaction between frailty and malnutrition was confirmed (OR = 1.064, 95% CI: 1.047-1.082). Significant positive additive interaction was also identified: RERI = 1.58 (95% CI: 0.19-2.96), AP = 0.10 (95% CI: 0.01-0.19), and SI = 1.18 (95% CI: 1.02-1.36). Conclusion: Frailty and malnutrition are correlated with high fall risk in older adults, with a modest positive interaction observed between the two conditions, offering empirical support for the development of comprehensive fall prevention and management strategies.

Indexed as

Accidental FallsFrail ElderlyFrailtyMalnutritionAgedAged, 80 and overCross-Sectional StudiesFemaleGeriatric AssessmentHumansLogistic ModelsMaleNutrition AssessmentRisk Factorsfallsfrailtyinteractionmalnutritionolder adults

Identifiers

PMID42453170
PMCPMC13366073

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.