ArticleFrontiers in aging neuroscience2026
Baseline facial emotion recognition is associated with clinical decline across the Alzheimer's disease spectrum: a multi-instrument longitudinal assessment study.
Article in Frontiers in aging neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Facial emotion recognition (FER) is increasingly recognized as a functionally relevant domain in the Alzheimer's disease (AD) spectrum, yet whether baseline FER is associated with subsequent clinical decline remains insufficiently established. Methods: We studied 328 participants [subjective cognitive decline (SCD) Results: FER_mean decreased stepwise across groups at baseline (SCD 17.3 ± 1.5, MCI 16.4 ± 2.1, AD 15.3 ± 2.0; Conclusion: Baseline FER was modestly associated with longitudinal worsening in clinical severity (CDR-SOB), but not cognitive screening performance (MMSE) across the pre-dementia to dementia spectrum. FER trajectories showed limited correlation with traditional measures. These findings indicate that FER may have a potential complementary role of social cognitive assessment in the AD continuum, pending further validation.
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