ReviewFrontiers in bioengineering and biotechnology2026
Piezoelectric scaffolds for bone regeneration: a systematic review of preclinical studies.
Review in Frontiers in bioengineering and biotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: Critical-sized bone defects remain a major challenge and often require reconstruction grafts. Conventional scaffolds don't reproduce the dynamic electromechanical behavior of native bone. Piezoelectric scaffolds have emerged as a promising strategy to overcome these limitations by converting mechanical stimuli into bioactive electrical signals capable of enhancing osteogenesis. Methods: A systematic review was conducted in accordance with the PRISMA 2020 guidelines and registered in PROSPERO (ID: 1359740). A comprehensive search of PubMed/MEDLINE, Scopus, Embase, and Cochrane Central Register of Controlled Trials was performed. Results: Ten preclinical Conclusion: Piezoelectric scaffolds represent a promising approach for bone regeneration, demonstrating superior regenerative performance compared with conventional scaffolds in preclinical models. Their ability to generate bioactive electrical signals, combined with advanced fabrication techniques, supports their potential for clinical translation. However, current evidence is limited to preclinical studies with heterogeneous methodologies. Further standardized studies and clinical investigations are needed to confirm their safety, efficacy, and long-term performance.
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