Evidence map›Paper›PMID 42453099›Full record

ArticleNAR molecular medicine2026

DNA adduct and mutational profiles reveal a threshold of cellular defenses against

Nina E Gubina, Lindsay B Volk, Anna F Dormitzer, Emily M Michelsen, Lee J Pribyl, Joshua J Corrigan, Esha D Dalvie, Amanda L Armijo, Monét Norales, Nicolette A Bugher and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NAR molecular medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Nina E GubinaDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, United States.ORCID https://orcid.org/0000-0003-1706-1451
Lindsay B VolkDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, United States.ORCID https://orcid.org/0000-0001-8472-3836
Anna F DormitzerDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, United States.
Emily M MichelsenDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, United States.
Lee J PribylDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, United States.ORCID https://orcid.org/0000-0003-0209-7814
Joshua J CorriganDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, United States.ORCID https://orcid.org/0009-0006-6252-4960
Esha D DalvieDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, United States.
Amanda L ArmijoDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, United States.ORCID https://orcid.org/0000-0002-4868-4355
Monét NoralesDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, United States.
Nicolette A BugherCenter for Environmental Health Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, United States.
Kayla M SchonviskyDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, United States.
Desiree L PlataCenter for Environmental Health Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, United States.
Bevin P EngelwardDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, United States.ORCID https://orcid.org/0000-0003-4322-3573
Robert G CroyDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, United States.
John M EssigmannDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, United States.ORCID https://orcid.org/0000-0002-2196-5691
Bogdan I FedelesDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, United States.ORCID https://orcid.org/0000-0001-5252-826X

Funding

TOXICOLOGY CORE UNITP30ES002109 · NIEHS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI NILES, JACQUIN C · 1985 to 2020
$25.6M
The MIT Superfund Research Program: A Systems Approach for the Protection of Human Health from Hazardous ChemicalsP42ES027707 · NIEHS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI Stuart S Levine · 2017 to 2026
$22.2M
TRAINING GRANTS IN ENVIROMENTAL TOXICOLOGYT32ES007020 · NIEHS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI ESSIGMANN, JOHN M · 1985 to 2024
$13.1M
Intra and Extra-Chromosomal Probes for Mutagenesis by CarcinogensR01CA080024 · NCI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI ESSIGMANN, JOHN M · 1998 to 2025
$5.9M
Cross-Disciplinary Research Training for Veterinary StudentsT35OD033655 · OD · TUFTS UNIVERSITY BOSTON · PI Cheryl A London, Kelly Ann Metcalf Pate · 2022 to 2026
$459k
Leveraging mutational analysis of cell-free DNA to identify carcinogenic exposure and enable early detection of cancerR21ES036341 · NIEHS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI FEDELES, BOGDAN I · 2024 to 2025
$437k
NCI NIH HHS R01 CA080024NIEHS NIH HHS P30 ES002109NIEHS NIH HHS P42 ES027707NIEHS NIH HHS R21 ES036341NIEHS NIH HHS T32 ES007020NIH HHS T35 OD033655
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Identifiers

PMID42453099
PMCPMC13366095

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.