Evidence map›Paper›PMID 42452999›Full record

SynthesisGeriatrics & gerontology international2026

Subsyndromal Delirium in Elderly Critical Care Patients: A Meta-Analysis of Prevalence and Risk Factors.

Juan Chen, Zarina Haron, Norafisyah Makhdzir, Youran Liu

Abstract readMeta-AnalysisSystematic Review
In one paragraph

Synthesis in Geriatrics & gerontology international, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Juan ChenDepartment of Nursing, Faculty of Medicine and Health Sciences, Universiti Putra, Selangor, Malaysia.ORCID https://orcid.org/0009-0009-9528-1928
Zarina HaronDepartment of Nursing, Faculty of Medicine and Health Sciences, Universiti Putra, Selangor, Malaysia.
Norafisyah MakhdzirDepartment of Nursing, Faculty of Medicine and Health Sciences, Universiti Putra, Selangor, Malaysia.ORCID https://orcid.org/0000-0002-7300-4083
Youran LiuThe Nethersole School of Nursing, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimsTo determine the pooled prevalence of subsyndromal delirium (SSD) in elderly critical care patients and synthesize evidence on its modifiable risk factors through meta-analysis. STUDY

designMeta-analysis.

methodsThis meta-analysis was conducted using six databases: PubMed, Web of Science, Embase, Cochrane Library, Scopus, and EBSCO. We assessed the quality of included studies using the Newcastle-Ottawa Scale and the Agency for Healthcare Research and Quality recommendation checklist. A meta-analysis of the predictive performance was conducted using the forest plot package in R 3.6.1.

resultsThis review included 12 studies involving 2428 participants. The pooled prevalence of SSD ranged from 11.7% to 71.4%. 0.12 studies reported 19 independent risk factors associated with SSD: older age, male sex, absence of a partner, education level ≤ 9 years, lower cognitive function, comorbidities, anemia, hyponatremia, higher C-reactive protein levels, pain, fall history, complicated procedures, previous brain failure in the ICU, preoperative fasting time, number of medications, decreased grip strength, low ADL, smoking, deafness.

conclusionThis meta-analysis demonstrates that SSD is a common condition among elderly critical-care patients. Future investigations should employ multicenter designs with larger, more diverse patient cohorts and standardized SSD assessment protocols to enhance the robustness of evidence. IMPLICATION OF PRACTICE: This review provides updated evidence that modifiable risk factors are significantly associated with SSD in critically ill older adults. Consequently, it offers solid information to inform targeted prevention strategies and underscores the importance of early recognition by healthcare professionals in geriatric psychiatry and critical care. REPORTING

methodThe research results were reported in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-analysis checklist. NO PATIENT OR PUBLICATION CONTRIBUTION: This study is a meta-analysis, and such details do not apply to our work.

Indexed as

Critical CareCritical IllnessDeliriumAgedFemaleHumansMalePrevalenceRisk Factorsagedcritical caremeta‐analysisrisk factorssubsyndromal delirium

Identifiers

PMID42452999
PMCPMC13370139

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.