Peptide-Based Pseudo[2]- and [3]rotaxanes Assembled via Square-Planar Palladium Coordination.

Takuma Shinoda, Chouma Kurihashi, Akio Miyazato, Issey Osaka, Koji Yamamoto, Yasuhito Koyama

Abstract read

In one paragraph

Article in ChemPlusChem, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Takuma ShinodaDepartment of Pharmaceutical Engineering, Toyama Prefectural University, Imizu, Toyama, Japan.

Chouma KurihashiDepartment of Pharmaceutical Engineering, Toyama Prefectural University, Imizu, Toyama, Japan.

Akio MiyazatoCenter for Nano Materials and Technology, Japan Advanced Institute of Science and Technology (JAIST), Nomi, Ishikawa, Japan.

Issey OsakaDepartment of Pharmaceutical Engineering, Toyama Prefectural University, Imizu, Toyama, Japan.ORCID https://orcid.org/0000-0002-3642-2278

Koji YamamotoDepartment of Pharmaceutical Engineering, Toyama Prefectural University, Imizu, Toyama, Japan.

Yasuhito KoyamaDepartment of Pharmaceutical Engineering, Toyama Prefectural University, Imizu, Toyama, Japan.ORCID https://orcid.org/0000-0002-6985-4499

Funding

Daiichi Sankyo Foundation of Life ScienceNaito FoundationTamura Science and Technology Foundation

6 · The paper itself

Abstract

Interlocked peptide molecules exhibit peptidase resistance as well as enzyme inhibitory activity, making them promising candidates for peptide-based drugs. Lasso peptides possess a [1]rotaxane structure, in which a peptide chain threads through the cavity of the cyclic peptide moiety. However, the construction of such peptide-based interlocked structures remains highly challenging, and the total chemical synthesis of natural lasso peptides has not yet been achieved. Here, we aim to develop a synthetic method for a peptide-based rotaxane using a metal-template strategy. A macrocyclic complex bearing a Pd(II) ion fixed by a pincer ligand is employed to examine the threading of Val-8mer in DMSO. Pseudorotaxane formation is assessed by characteristic

Indexed as

diffusion‐ordered spectroscopyelectrospray ionization mass spectrometrylasso peptidemetal‐template methodpseudorotaxane

Identifiers

PMID42452910

DOI10.1002/cplu.70210

PMCPMC13370049

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.