Evidence map›Paper›PMID 42452792›Full record

ReviewInternational journal of stem cells2026

Vascularized Brain Organoids: Advances in Engineering Human Neurovascular Models.

Hee Young Kim, Jung Eun Lee, Seung Ho Yang, Jai Ho Choi

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in International journal of stem cells, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Hee Young KimDepartment of Neurosurgery, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.ORCID https://orcid.org/0009-0009-3066-0863
Jung Eun LeeDepartment of Neurosurgery, St. Vincent's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.ORCID https://orcid.org/0000-0002-8401-2839
Seung Ho YangDepartment of Neurosurgery, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.ORCID https://orcid.org/0000-0002-3490-1064
Jai Ho ChoiDepartment of Neurosurgery, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.ORCID https://orcid.org/0000-0001-6838-0343

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Brain organoids have emerged as an important platform for studying human neurodevelopment and neurological disorders, yet their physiological relevance remains limited by the absence of a functional vascular network. Recent efforts therefore focus on developing vascularized brain organoids (vBOs) to better recapitulate neurovascular interactions. Here, we investigate current strategies for vBO engineering, discussing its potential implications such as disease modeling, drug screening, and regenerative therapies along with persistent challenges in reproducing physiologically mature neurovascular features. This review outlines a rapidly evolving framework that enhances neurovascular modeling and supports emerging translational research in neurological disorders.

Indexed as

Blood-brain barrierCerebrovascular disordersNeurovascular couplingOrganoidsPluripotent stem cells

Identifiers

PMID42452792
PMCPMC13519547

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.