Evidence map›Paper›PMID 42452622›Full record

ArticleJournal of clinical medicine2026

Intravitreal Brolucizumab for Diabetic Macular Edema: Outcomes in Treatment-Naive and Anti-VEGF-Switched Eyes over 48 Weeks.

Fumiaki Higashijima, Yugo Ota, Hikaru Jiromaru, Yoshinao Tamura, Masahiko Funatsu, Ren Aoki, Masanori Mikuni, Manami Ohta, Makiko Wakuta, Shinji Hirano and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of clinical medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Fumiaki HigashijimaDepartment of Ophthalmology, Yamaguchi University Graduate School of Medicine, Ube 755-8505, Yamaguchi, Japan.ORCID 0000-0002-3428-852X
Yugo OtaDepartment of Ophthalmology, Yamaguchi University Graduate School of Medicine, Ube 755-8505, Yamaguchi, Japan.
Hikaru JiromaruDepartment of Ophthalmology, Yamaguchi University Graduate School of Medicine, Ube 755-8505, Yamaguchi, Japan.
Yoshinao TamuraDepartment of Ophthalmology, Yamaguchi University Graduate School of Medicine, Ube 755-8505, Yamaguchi, Japan.
Masahiko FunatsuDepartment of Ophthalmology, Yamaguchi University Graduate School of Medicine, Ube 755-8505, Yamaguchi, Japan.
Ren AokiDepartment of Ophthalmology, Yamaguchi University Graduate School of Medicine, Ube 755-8505, Yamaguchi, Japan.
Masanori MikuniDepartment of Ophthalmology, Yamaguchi University Graduate School of Medicine, Ube 755-8505, Yamaguchi, Japan.
Manami OhtaDepartment of Ophthalmology, Yamaguchi University Graduate School of Medicine, Ube 755-8505, Yamaguchi, Japan.
Makiko WakutaDepartment of Ophthalmology, Yamaguchi University Graduate School of Medicine, Ube 755-8505, Yamaguchi, Japan.ORCID 0000-0002-9910-770X
Shinji HiranoDepartment of Ophthalmology, Yamaguchi University Graduate School of Medicine, Ube 755-8505, Yamaguchi, Japan.
Kazuhiko YamauchiYamaguchi Red Cross Hospital, Yamaguchi 753-0092, Yamaguchi, Japan.
Kazuhiro KimuraDepartment of Ophthalmology, Yamaguchi University Graduate School of Medicine, Ube 755-8505, Yamaguchi, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

anti-VEGFbrolucizumabdiabetic macular edemaoptical coherence tomographypro re natareal-worldswitchedtreatment-naive

Identifiers

PMID42452622
PMCPMC13362911

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.