Evidence map›Paper›PMID 42452577›Full record

ReviewJournal of clinical medicine2026

Stratified Psychosocial Care in Assisted Reproductive Technologies: A Narrative Review and Conceptual Framework Across the IVF Pathway.

Giuseppe Marano, Giulio Carriero, Elena Lucia Valle, Caterina Brisi, Gianandrea Traversi, Osvaldo Mazza, Claudia d'Abate, Rosanna Esposito, Gabriele Sani, Marianna Mazza

Abstract readReview
In one paragraph

Review in Journal of clinical medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Giuseppe MaranoDepartment of Neuroscience, Head-Neck and Chest, Section of Psychiatry, Fondazione Policlinico, Universitario Agostino Gemelli IRCCS, Largo Agostino Gemelli 8, 00168 Rome, Italy.ORCID 0000-0001-7058-4927
Giulio CarrieroDepartment of Neuroscience, Head-Neck and Chest, Section of Psychiatry, Fondazione Policlinico, Universitario Agostino Gemelli IRCCS, Largo Agostino Gemelli 8, 00168 Rome, Italy.
Elena Lucia ValleDepartment of Neuroscience, Head-Neck and Chest, Section of Psychiatry, Fondazione Policlinico, Universitario Agostino Gemelli IRCCS, Largo Agostino Gemelli 8, 00168 Rome, Italy.ORCID 0009-0007-6520-0686
Caterina BrisiDepartment of Neuroscience, Head-Neck and Chest, Section of Psychiatry, Fondazione Policlinico, Universitario Agostino Gemelli IRCCS, Largo Agostino Gemelli 8, 00168 Rome, Italy.
Gianandrea TraversiUnit of Medical Genetics, Department of Laboratory Medicine, Ospedale Isola Tiberina-Gemelli Isola, 00186 Rome, Italy.ORCID 0000-0002-6558-2932
Osvaldo MazzaSpine Surgery Department, Bambino Gesù Children's Hospital IRCCS, 00168 Rome, Italy.
Claudia d'AbateDepartment of Gynecology, San Carlo Nancy Hospital, 00165 Rome, Italy.ORCID 0009-0004-4688-9228
Rosanna EspositoUnit of Gynecology and Obstetrics, A.O.R.N. Antonio Cardarelli Hospital, 80131 Naples, Italy.
Gabriele SaniDepartment of Neuroscience, Head-Neck and Chest, Section of Psychiatry, Fondazione Policlinico, Universitario Agostino Gemelli IRCCS, Largo Agostino Gemelli 8, 00168 Rome, Italy.ORCID 0000-0002-9767-8752
Marianna MazzaDepartment of Neuroscience, Head-Neck and Chest, Section of Psychiatry, Fondazione Policlinico, Universitario Agostino Gemelli IRCCS, Largo Agostino Gemelli 8, 00168 Rome, Italy.ORCID 0000-0002-3007-8162

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Assisted reproductive technologies (ART), particularly in vitro fertilization (IVF), are characterized by substantial emotional burden, uncertainty, and repeated decision-making under probabilistic conditions. Although psychological distress is common among individuals and couples undergoing ART, psychosocial care remains inconsistently integrated into fertility pathways and is rarely tailored to individual needs. This narrative review synthesizes evidence concerning infertility-related distress, anxiety and depressive symptoms, couple functioning, treatment discontinuation, psychosocial screening, and psychological interventions across the IVF trajectory. Key phases of treatment, including pretreatment assessment, ovarian stimulation, embryo transfer, the waiting period, cycle outcome, and decisions regarding repetition or discontinuation, are described, and phase-specific psychological vulnerabilities are identified. On the basis of the available literature, we propose a conceptual stepped-care framework ranging from universal psychoeducation and routine monitoring to structured psychological interventions, couple-based care, and specialist psychiatric management. Practical screening thresholds, referral criteria, reassessment intervals, and a safety pathway for suicidal ideation are outlined. Particular attention is given to male-factor infertility, strategies for engaging male partners, and the ethical and data-governance requirements of digital mental health tools. Current evidence supports psychosocial interventions for improving emotional well-being and quality of life and suggests a potential role in treatment continuation, but their effects on pregnancy and live-birth outcomes remain uncertain. The proposed framework should therefore be regarded as a clinically informed conceptual model rather than a validated prediction algorithm. Prospective studies are required to assess its feasibility, predictive performance, cost-effectiveness, and impact on patient-centered outcomes.

Indexed as

assisted reproductive technologiesinfertility-related distressIVFmental healthprecision psychosocial carescreening

Identifiers

PMID42452577
PMCPMC13363067

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.