Mechanical-Enhanced Porous Silk-Based Cryogenic Microneedles for Cell Thawing/Revival in the Gastric Wall.

Zhiwei Yin, Limin Zhang, Rui Shi, Xin Xia, Zhaoxin Wang, Ling Li, Zhuo Chen

Abstract read

In one paragraph

Article in Polymers, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Zhiwei YinThe University of Hong Kong Shenzhen Institute of Research and Innovation, Shenzhen 518048, China.

Limin ZhangThe University of Hong Kong Shenzhen Institute of Research and Innovation, Shenzhen 518048, China.

Rui ShiMolecular Science and Biomedicine Laboratory (MBL), State Key Laboratory of Chemo and Biosensing, College of Chemistry and Chemical Engineering, College of Environmental Science and Engineering, Aptamer Engineering Center of Hunan Province, Hunan University, Changsha 410082, China.

Xin XiaMolecular Science and Biomedicine Laboratory (MBL), State Key Laboratory of Chemo and Biosensing, College of Chemistry and Chemical Engineering, College of Environmental Science and Engineering, Aptamer Engineering Center of Hunan Province, Hunan University, Changsha 410082, China.

Zhaoxin WangMolecular Science and Biomedicine Laboratory (MBL), State Key Laboratory of Chemo and Biosensing, College of Chemistry and Chemical Engineering, College of Environmental Science and Engineering, Aptamer Engineering Center of Hunan Province, Hunan University, Changsha 410082, China.

Ling LiMolecular Science and Biomedicine Laboratory (MBL), State Key Laboratory of Chemo and Biosensing, College of Chemistry and Chemical Engineering, College of Environmental Science and Engineering, Aptamer Engineering Center of Hunan Province, Hunan University, Changsha 410082, China.

Zhuo ChenMolecular Science and Biomedicine Laboratory (MBL), State Key Laboratory of Chemo and Biosensing, College of Chemistry and Chemical Engineering, College of Environmental Science and Engineering, Aptamer Engineering Center of Hunan Province, Hunan University, Changsha 410082, China.ORCID 0000-0002-9943-2262

Funding

China Postdoctoral Science Foundation 2024M762157China Postdoctoral Science Foundation 2025T180793National Natural Science Foundation of China 22225401National Natural Science Foundation of China 22505070the Fundamental and Interdisciplinary Disciplines Breakthrough Plan of the Ministry of Educa-tion of China JYB2025XDXM602

6 · The paper itself

Abstract

Cell therapies for gastric disorders lack minimally invasive delivery platforms that preserve cell viability during storage and enable effective tissue penetration, owing to the high toughness and harsh environment of the gastric wall. Herein, we developed a mechanically reinforced, porous silk-based cryogenic microneedle (silk-cryoMN) platform for in situ cell delivery to the gastric wall. The optimized 1.5% (

Indexed as

cell therapycryogenic microneedlegastric wall penetrationporous silk scaffoldβ-sheet transformation

Identifiers

PMID42452111

DOI10.3390/polym18131654

PMCPMC13363972

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.