ArticleMaterials (Basel, Switzerland)2026
Cationic Amphiphiles with Five-Membered Heterocyclic Linkers: Synthesis, Self-Assembly, and DNA Complexation Properties.
Article in Materials (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Lipid-based nanoparticles are widely explored as non-viral vectors for nucleic acid delivery, where the molecular structure of cationic lipids strongly determines their performance. Five-membered heterocyclic linkers were explored as a new structural motif in cationic amphiphilic lipids for the development of promising gene delivery candidates. Novel lipids incorporating pyrrole, furan, and thiophene linkers were synthesized alongside structurally related aliphatic analogues, enabling systematic evaluation of how linker type influences physicochemical behavior and self-assembly properties. Self-assembly behavior in aqueous media was characterized by dynamic light scattering, and
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