Evidence map›Paper›PMID 42451747›Full record

ArticleMolecules (Basel, Switzerland)2026

Synthesis and Antibacterial Activity of Novel

Meglena I Kandinska, Peter G Boyadzhiev, Trayana S Nedeva, Stanimira T Ivanova, Viliana D Miteva, Asya A Asenova, Vesela V Lozanova, Valentin S Lozanov, Iliyana K Rasheva

Abstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Meglena I KandinskaFaculty of Chemistry and Pharmacy, Sofia University "St. Kliment Ohridski", 1 James Bourchier Blvd., 1164 Sofia, Bulgaria.ORCID 0000-0002-0426-2820
Peter G BoyadzhievFaculty of Chemistry and Pharmacy, Sofia University "St. Kliment Ohridski", 1 James Bourchier Blvd., 1164 Sofia, Bulgaria.
Trayana S NedevaFaculty of Biology, Sofia University "St. Kliment Ohridski", 8 Dragan Tsankov Blvd., 1164 Sofia, Bulgaria.
Stanimira T IvanovaFaculty of Biology, Sofia University "St. Kliment Ohridski", 8 Dragan Tsankov Blvd., 1164 Sofia, Bulgaria.
Viliana D MitevaFaculty of Biology, Sofia University "St. Kliment Ohridski", 8 Dragan Tsankov Blvd., 1164 Sofia, Bulgaria.
Asya A AsenovaFaculty of Biology, Sofia University "St. Kliment Ohridski", 8 Dragan Tsankov Blvd., 1164 Sofia, Bulgaria.ORCID 0009-0001-0673-342X
Vesela V LozanovaDepartment of Medical Chemistry and Biochemistry, Medical Faculty, Medical University-Sofia, 2 Zdrave Str., 1431 Sofia, Bulgaria.ORCID 0000-0002-7748-4133
Valentin S LozanovDepartment of Medical Chemistry and Biochemistry, Medical Faculty, Medical University-Sofia, 2 Zdrave Str., 1431 Sofia, Bulgaria.
Iliyana K RashevaFaculty of Biology, Sofia University "St. Kliment Ohridski", 8 Dragan Tsankov Blvd., 1164 Sofia, Bulgaria.ORCID 0000-0001-8490-9243

Funding

Bulgarian National Science Fund (BNSF) Project KP-06-COST/20 from 25 August 2025EU and Bulgarian Government PRIDST 2021-2027European Union Next Generation EU BG-RRP-2.004-0008-C01
6 · The paper itself

Abstract

Foodborne diseases remain a major global public health concern. According to the World Health Organization (WHO), contaminated food causes nearly 500,000 deaths annually. Consequently, the development of novel strategies to control foodborne pathogens and prevent microorganism-induced plant diseases remains an important research priority, attracting considerable scientific attention worldwide. This study describes the design and synthesis of novel dihydropyrazolines containing an ethylpiperazine moiety as potential antimicrobial agents. The antibacterial activity of the newly synthesized heterocyclic compounds, along with their corresponding chalcone precursors, was evaluated against Gram-positive and Gram-negative foodborne pathogens and phytopathogenic bacteria. The assessment was performed using a two-step protocol comprising an initial qualitative screening of selected bacterial species, followed by a quantitative evaluation of the inhibitory effects of individual compounds and their combinations. Among the tested compounds, pyrazolines

Indexed as

Anti-Bacterial AgentsBacteriaChalconePyrazolesChalconesFoodborne DiseasesMicrobial Sensitivity TestsMolecular StructureAnti-Bacterial AgentsChalconeChalconesPyrazoleschalconedihydropyrazolinefoodborne pathogens and phytopathogensN-Ethylpiperazine

Identifiers

PMID42451747
PMCPMC13362652

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.