Evidence map›Paper›PMID 42451704›Full record

ArticleMolecules (Basel, Switzerland)2026

Development, Validation, and Application of an HPLC Method Combined with an In Vitro Model for the Determination of Antibiotic Binding to the Haemoadsorber CytoSorb

Sara Kenda, Jakob Gubenšek, Tomaž Vovk

Abstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Sara KendaFaculty of Pharmacy, University of Ljubljana, Askerceva 7, 1000 Ljubljana, Slovenia.ORCID 0009-0003-3879-3042
Jakob GubenšekDepartment of Nephrology, University Medical Center Ljubljana, Zaloska 7, 1000 Ljubljana, Slovenia.ORCID 0000-0002-5394-3729
Tomaž VovkFaculty of Pharmacy, University of Ljubljana, Askerceva 7, 1000 Ljubljana, Slovenia.ORCID 0000-0002-3322-4807

Funding

The Slovenian Research and Innovation Agency ARIS Grant P1-0189 and P3-0323
6 · The paper itself

Abstract

Supportive therapy with haemoadsorption is gaining popularity in critically ill patients, with the aim of reducing overinflammation triggered by the cytokine storm. The haemoadsorbers used are not specific for cytokines and also bind antibiotics. The aim of this study was to develop and validate a simple analytical method for the simultaneous determination of selected antibiotics and to develop an in vitro model for the quantification of their binding to the CytoSorb

Indexed as

Anti-Bacterial AgentsAmoxicillinAnimalsCattleCefepimeChromatography, High Pressure LiquidImipenemMeropenemPiperacillinReproducibility of ResultsVancomycinAmoxicillinAnti-Bacterial AgentsCefepimeImipenemMeropenemPiperacillinVancomycinantibioticscritically illCytoSorb®gradient elutionhaemoadsorptionhemoadsorptionin vitro model

Identifiers

PMID42451704
PMCPMC13363450

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.