ArticleMolecules (Basel, Switzerland)2026
Arylidenehydrazinyl 4-Methylthiazole-5-carboxylates: Synthesis, Antileishmanial Activity, and Targeting of Trypanothione Synthetase.
Brunno da S Souza, Hasnain Mehmood, Estela M Nolasco, Muhammad Haroon, Tashfeen Akhtar, Nathalia da Silva Brito, Adilson Beatriz, Nikhil Sodhi, Vijay P Singh, Amilcar Machulek and 5 more
Abstract read
In one paragraphArticle in Molecules (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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0citing papers in PubMed
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What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
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0 citing papers in PubMed.
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
15 authors.
Brunno da S SouzaLaboratório de Síntese Sustentável e Organocalcogênio (LabSO), Instituto de Química (IQ), Universidade Federal de Goiás (UFG), Goiânia 74690-900, GO, Brazil.ORCID 0009-0007-0875-5204 Hasnain MehmoodDepartment of Chemistry, Mirpur University of Science and Technology (MUST), Mirpur 10250, AJK, Pakistan.ORCID 0000-0003-0997-3231 Estela M NolascoFaculdade de Ciências Farmacêuticas, Alimentos e Nutrição (FACFAN), Universidade Federal do Mato Grosso do Sul (UFMS), Campo Grande 79074-460, MS, Brazil.
Muhammad HaroonDepartment of Chemistry, Mirpur University of Science and Technology (MUST), Mirpur 10250, AJK, Pakistan.ORCID 0000-0002-7386-5107 Tashfeen AkhtarDepartment of Chemistry, Mirpur University of Science and Technology (MUST), Mirpur 10250, AJK, Pakistan.ORCID 0000-0002-4815-0687 Nathalia da Silva BritoLaboratório de Síntese Sustentável e Organocalcogênio (LabSO), Instituto de Química (IQ), Universidade Federal de Goiás (UFG), Goiânia 74690-900, GO, Brazil.
Adilson BeatrizInstituto de Química (INQUI), Universidade Federal do Mato Grosso do Sul (UFMS), Campo Grande 79074-460, MS, Brazil.ORCID 0000-0001-6864-6092 Nikhil SodhiDepartment of Chemistry & Centre of Advanced Studies in Chemistry, Panjab University, Chandigarh 160014, Punjab, India.ORCID 0000-0002-9611-1375 Vijay P SinghDepartment of Chemistry & Centre of Advanced Studies in Chemistry, Panjab University, Chandigarh 160014, Punjab, India.ORCID 0000-0002-5584-2067 Amilcar MachulekInstituto de Química, Universidade Federal do Rio Grande do Norte (UFRN), Av. Senador Salgado Filho, s/n, Natal 59078-970, RN, Brazil.ORCID 0000-0002-4632-4647 Gleison A CasagrandeInstituto de Química (INQUI), Universidade Federal do Mato Grosso do Sul (UFMS), Campo Grande 79074-460, MS, Brazil.
Dênis Pires de LimaInstituto de Química (INQUI), Universidade Federal do Mato Grosso do Sul (UFMS), Campo Grande 79074-460, MS, Brazil.ORCID 0000-0002-6023-4867 Sumbal SabaLaboratório de Síntese Sustentável e Organocalcogênio (LabSO), Instituto de Química (IQ), Universidade Federal de Goiás (UFG), Goiânia 74690-900, GO, Brazil.ORCID 0000-0002-6134-7249 Thalita B RiulFaculdade de Ciências Farmacêuticas, Alimentos e Nutrição (FACFAN), Universidade Federal do Mato Grosso do Sul (UFMS), Campo Grande 79074-460, MS, Brazil.ORCID 0000-0002-4298-6475 Jamal RafiqueLaboratório de Síntese Sustentável e Organocalcogênio (LabSO), Instituto de Química (IQ), Universidade Federal de Goiás (UFG), Goiânia 74690-900, GO, Brazil.ORCID 0000-0002-2336-040X Funding
Conselho Nacional de Desenvolvimento Científico e Tecnológico 308875/2026-5Conselho Nacional de Desenvolvimento Científico e Tecnológico 309975/2022-0Conselho Nacional de Desenvolvimento Científico e Tecnológico 316687/2023-5Conselho Nacional de Desenvolvimento Científico e Tecnológico 401355/2025-0Conselho Nacional de Desenvolvimento Científico e Tecnológico 404172/2023-7Conselho Nacional de Desenvolvimento Científico e Tecnológico 405655/2023-1Coordenação de Aperfeicoamento de Pessoal de Nível Superior 001Foundation for Research Support of Goiás State FAPEG/SES Nº 18/2025 (ARB2025191000003)Universidade Federal de Mato Grosso do Sul 001
6 · The paper itselfAbstract
BACKGROUND/
objectivesLeishmaniases are a group of neglected tropical diseases that have been overlooked, and new treatments are needed. This is because the parasites that cause it, from the
methodsHere, we report the synthesis of a series of arylidenehydrazinyl thiazole carboxylates (
resultsAll compounds were fully characterized using spectroscopic techniques (
conclusionsThe compounds showed little or no cytotoxicity against NIH/3T3 fibroblasts, compounds
Indexed as
Amide SynthasesAntiprotozoal AgentsCarboxylic AcidsLeishmaniaThiazolesAnimalsMiceMolecular Docking SimulationMolecular StructureStructure-Activity RelationshipAmide SynthasesAntiprotozoal AgentsCarboxylic AcidsThiazolestrypanothione synthetasearylidenehydrazinyl thiazoleLeishmania amazonensismolecular docking
Identifiers
PMID42451646
PMCPMC13362754
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