Strengthening D-A Push-Pull Interactions in BODIPY to Enhance Near-Infrared Absorption and Photothermal Conversion for Low-Intensity Photothermal Antitumor Therapy.

Yamin Li, Xiaolu Weng, Jianyong Liu

Abstract read

In one paragraph

Article in Molecules (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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5 · Who and what money

Authors and funding

3 authors.

Yamin LiKey Laboratory of Molecule Synthesis and Function Discovery, Fujian Province University, College of Chemistry, Fuzhou University, Fuzhou 350108, China.

Xiaolu WengKey Laboratory of Molecule Synthesis and Function Discovery, Fujian Province University, College of Chemistry, Fuzhou University, Fuzhou 350108, China.

Jianyong LiuKey Laboratory of Molecule Synthesis and Function Discovery, Fujian Province University, College of Chemistry, Fuzhou University, Fuzhou 350108, China.ORCID 0000-0003-3349-6623

Funding

Fujian Provincial Key Laboratory of Hepatic Drug Research KFLX2022001Natural Science Foundation of Fujian Province 2024J01237

6 · The paper itself

Abstract

Conventional photothermal therapy often relies on high-intensity laser excitation due to the limited photothermal conversion efficiency (PCE) of existing photothermal agents (PTAs), which compromises treatment safety and restricts clinical translation. To address this limitation, we designed and synthesized a series of boron-dipyrromethene (BODIPY)-based derivatives (BDP 1-4) featuring gradient-enhanced donor-acceptor (D-A) push-pull electronic effects for efficient photothermal antitumor therapy. The structure-activity relationships were systematically elucidated through photophysical characterization and in vitro/in vivo photobiological evaluation. From BDP 1 to BDP 4, the progressively strengthened push-pull effect leads to enhanced intramolecular charge transfer (ICT), which, in turn, results in a narrowed HOMO-LUMO gap, redshifted absorption into the near-infrared (NIR) region (up to 843 nm), markedly attenuated fluorescence emission, and a remarkable increase in PCE up to 88.3%. To improve water dispersibility and tumor targeting, these molecules were further encapsulated into nanoparticles using DSPE-PEG

Indexed as

Antineoplastic AgentsBoron CompoundsPhotothermal TherapyAnimalsCell Line, TumorHumansInfrared RaysMiceNanoparticlesStructure-Activity Relationship4,4-difluoro-4-bora-3a,4a-diaza-s-indaceneAntineoplastic AgentsBoron CompoundsBODIPYnanoparticlesphotothermal conversion efficiencyphotothermal therapypush-pull electronic effect

Identifiers

PMID42451626

DOI10.3390/molecules31132258

PMCPMC13363352

What OpenQuestion holds

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LicenceCC BY

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.