Evidence map›Paper›PMID 42451607›Full record

ArticleMolecules (Basel, Switzerland)2026

Identification of Pyrrolo [2,3-

Shuai Wen, Can Xiao, Li-Min Du, Jing Ji, Hong-Kai Sha, Shun-Xin-Wang Lin, Yi Mou, Hao Sun, Zheng-Yu Jiang

Abstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Shuai WenCollege of Pharmacy, Taizhou University, Taizhou 225300, China.
Can XiaoJiangsu Key Laboratory of Drug Design and Optimization, China Pharmaceutical University, Nanjing 210009, China.
Li-Min DuJiangsu Key Laboratory of Drug Design and Optimization, China Pharmaceutical University, Nanjing 210009, China.
Jing JiCollege of Pharmacy, Taizhou University, Taizhou 225300, China.
Hong-Kai ShaCollege of Pharmacy, Taizhou University, Taizhou 225300, China.
Shun-Xin-Wang LinNanjing Linkinovo Biological Technology Research Institute, Nanjing 211100, China.
Yi MouCollege of Pharmacy, Taizhou University, Taizhou 225300, China.
Hao SunNanjing Linkinovo Biological Technology Research Institute, Nanjing 211100, China.
Zheng-Yu JiangJiangsu Key Laboratory of Drug Design and Optimization, China Pharmaceutical University, Nanjing 210009, China.ORCID 0000-0002-1671-1582

Funding

Nanjing Science and Technology Plan Project 202304009Natural Science Foundation of the Jiangsu Higher Education Institutions of China 24KJA350004 and 23KJB360016Taizhou Natural Science Foundation TZ202511
6 · The paper itself

Abstract

Treatment of inflammatory bowel disease (IBD) remains a major medical challenge due to the lack of safe and effective therapeutic agents. JAK1 has been validated as a key therapeutic target that modulates the pathological progression of IBD. In this study, using tofacitinib as the lead compound, we adopted a scaffold growth strategy to design and synthesize a series of pyrrolo [2,3-

Indexed as

Inflammatory Bowel DiseasesJanus Kinase 1Protein Kinase InhibitorsPyridinesPyrrolesAnimalsColitisDextran SulfateDisease Models, AnimalLipopolysaccharidesMicePhosphorylationPiperidinesPyrimidinesRAW 264.7 CellsSTAT1 Transcription FactorDextran SulfateJak1 protein, mouseJanus Kinase 1LipopolysaccharidesPiperidinesProtein Kinase InhibitorsPyridinesPyrimidinesPyrrolesSTAT1 Transcription FactorSTAT3 Transcription Factortofacitinibinflammatory bowel diseaseJAK1 inhibitorsscaffold growth strategytofacitinib

Identifiers

PMID42451607
PMCPMC13362992

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.