ArticleSensors (Basel, Switzerland)2026
Confined Internal Standard Core-Gap-Shell Nanoprobes for Ratiometric SERS Sensing of Urine pH.
Article in Sensors (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 authors.
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Abstract
Urine pH is an important biomarker related to metabolic status and urinary system health, but reliable SERS quantification in real urine remains limited by matrix interference, heterogeneous hotspot distribution, and the narrow response range of single pH-responsive molecules. Here, we report a core-gap-shell Au@1,4-BDT@Au@4-MBA/MPY nanoprobe for ratiometric SERS detection of urine pH. 1,4-BDT was confined within the gap between the gold core and shell as an internal standard, while 4-MBA and 4-MPY were co-assembled on the outer gold shell to provide complementary protonation/deprotonation responses. The internal standard-corrected ratio I
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