Evidence map›Paper›PMID 42451118›Full record

Trial reportNutrients2026

A Heat-Inactivated Two-Strain

Xinyi Li, Hanglian Lan, Yiran Guan, Langrun Wang, Wen Zhao, Jian He, Zhi Zhao, Meina Li, Qixu Han, Yifan Gong and 5 more

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Nutrients, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Xinyi LiKey Laboratory of Precision Nutrition and Food Quality, Department of Nutrition and Health, China Agricultural University, Beijing 100193, China.ORCID 0009-0008-6893-8456
Hanglian LanNational Technology Innovation Center for Dairy, Hohhot 010100, China.
Yiran GuanKey Laboratory of Precision Nutrition and Food Quality, Department of Nutrition and Health, China Agricultural University, Beijing 100193, China.
Langrun WangKey Laboratory of Precision Nutrition and Food Quality, Department of Nutrition and Health, China Agricultural University, Beijing 100193, China.
Wen ZhaoNational Technology Innovation Center for Dairy, Hohhot 010100, China.ORCID 0000-0002-0094-711X
Jian HeNational Technology Innovation Center for Dairy, Hohhot 010100, China.
Zhi ZhaoKey Laboratory of Precision Nutrition and Food Quality, Department of Nutrition and Health, China Agricultural University, Beijing 100193, China.
Meina LiKey Laboratory of Precision Nutrition and Food Quality, Department of Nutrition and Health, China Agricultural University, Beijing 100193, China.
Qixu HanKey Laboratory of Precision Nutrition and Food Quality, Department of Nutrition and Health, China Agricultural University, Beijing 100193, China.
Yifan GongKey Laboratory of Precision Nutrition and Food Quality, Department of Nutrition and Health, China Agricultural University, Beijing 100193, China.
Xinxin YanKey Laboratory of Precision Nutrition and Food Quality, Department of Nutrition and Health, China Agricultural University, Beijing 100193, China.
Ziwen LiSchool of Food and Health, Beijing Technology and Business University, Beijing 100048, China.
Jie GuoKey Laboratory of Precision Nutrition and Food Quality, Department of Nutrition and Health, China Agricultural University, Beijing 100193, China.
Ran WangResearch Center for Probiotics, China Agricultural University, Beijing 100190, China.
Jingjing HeKey Laboratory of Precision Nutrition and Food Quality, Department of Nutrition and Health, China Agricultural University, Beijing 100193, China.ORCID 0000-0002-2427-9064

Funding

China Association for Science and Technology 202404623140567National Technology Innovation Center for Dairy 2023-JSGG-28
6 · The paper itself

Abstract

BACKGROUND/

objectivesFunctional constipation (FC) commonly affects middle-aged and older adults, but current pharmacological treatments have limitations. Postbiotics may offer safety advantages, but clinical evidence is limited. This randomized controlled trial evaluated the efficacy and safety of a heat-inactivated two-strain

methodsOne hundred adults aged 45-75 years with Rome IV-defined FC received the fermented milk or placebo for 4 weeks. The primary outcome was the change in weekly spontaneous bowel movement (SBM) frequency from baseline to week 4. Secondary outcomes included complete spontaneous bowel movement (CSBM) frequency, whole-gut transit time (WGTT), constipation symptom scores, quality of life, serum biomarkers, and adverse events. Primary analysis was per-protocol (

resultsDropout was 4% (

conclusionsFour weeks of this postbiotic was safe but did not significantly improve bowel function or symptoms in the overall FC population. The increases in serum VIP and ACh suggest engagement of neurotransmitter-related pathways; however, these exploratory findings do not imply causation or clinical efficacy and warrant confirmation in longer-duration trials (Clinical Trial Registry: ChiCTR2500111771).

Indexed as

ConstipationCultured Milk ProductsLacticaseibacillus paracaseiProbioticsAgedAnimalsBiomarkersDouble-Blind MethodFemaleGastrointestinal TransitHot TemperatureHumansMaleMiddle AgedQuality of LifeTreatment OutcomeBiomarkersacetylcholinefunctional constipationheat-inactivated Lacticaseibacillus paracaseirandomized controlled trialvasoactive intestinal peptide

Identifiers

PMID42451118
PMCPMC13363550

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.