ArticleAnimals : an open access journal from MDPI2026
Subchondral Bone Density Distribution in Canine C6-C7 Vertebral Endplates Affected by DA-CSM: A CT-OAM Study.
Article in Animals : an open access journal from MDPI, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Disc-associated cervical spondylomyelopathy (DA-CSM) is a clinically relevant disorder of the canine cervical spine frequently requiring surgical stabilization, with implant subsidence remaining a common complication. This study aimed to evaluate subchondral bone mineral density (sBMD) distribution in the C6-C7 vertebral motion unit of DA-CSM-affected dogs and to compare these findings with a previously established cohort of clinically unaffected dogs. Computed tomography osteoabsorptiometry (CT-OAM) was applied to eight affected specimens, and sBMD was analyzed across predefined annulus fibrosus (AF) and nucleus pulposus (NP) regions, including detailed topographic subdivisions. Statistical comparisons were performed using paired and independent t-tests with correction for multiple testing, while the topographic pattern of bone density minima and maxima was compared using Chi-squared testings. DA-CSM-affected vertebral endplates demonstrated a consistent and significant reduction in overall sBMD compared to controls (
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