Evidence map›Paper›PMID 42450776›Full record

ArticleAnimals : an open access journal from MDPI2026

Multi-Omics Reveals Gut Microbiota Shifts and Hepatic Metabolic-Immune Alterations in "Short-Leg" Malformed Frog (

Dan Zeng, Qin Qin, Ming Yang, Zi'ao Wang, Jianguo Xiang, Xiaoqing Wang, Yazhou Hu

Abstract read
In one paragraph

Article in Animals : an open access journal from MDPI, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Dan ZengCollege of Life and Environmental Sciences, Hunan University of Arts and Science, Changde 415000, China.ORCID 0000-0002-7160-4173
Qin QinFisheries College, Hunan Agricultural University, Changsha 410128, China.
Ming YangJiangsu Coast Development Group Co., Ltd., Nanjing 210000, China.
Zi'ao WangCollege of Animal Science and Technology, Hunan Biological and Electromechanical Polytechnic, Changsha 410127, China.
Jianguo XiangFisheries College, Hunan Agricultural University, Changsha 410128, China.
Xiaoqing WangFisheries College, Hunan Agricultural University, Changsha 410128, China.
Yazhou HuFisheries College, Hunan Agricultural University, Changsha 410128, China.ORCID 0000-0002-8382-4608

Funding

Hunan Provincial Education Department Outstanding Youth Project 24B0625Natural Science Foundation of Hunan Province 2026JJ60022Research and Demonstration on the Innovation of the Black-Spotted Frog Breeding Model 25210010
6 · The paper itself

Abstract

Amphibian malformation syndromes significantly impact both conservation efforts and aquaculture, yet their underlying systemic pathophysiological mechanisms remain poorly characterized. This study comprehensively examines the multi-level pathological processes associated with the "short-leg" malformation syndrome in the black-spotted frog (

Indexed as

gut microbiotahepatic transcriptomeimmune–metabolic disruptionmalformation syndromePelophylax nigromaculatus

Identifiers

PMID42450776
PMCPMC13359810

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.