Evidence map›Paper›PMID 42450717›Full record

ArticleAnimals : an open access journal from MDPI2026

Targeted Intra-Articular PRGF Delivery Using Enzyme-Powered Nanobots for Chondral Lesions: A Prospective Experimental Study with Biomarker Evaluation in Rabbits (

Emma Martins, Belén Cuervo, María Gemma Velasco-Martínez, Rocío Colomer-Selva, María Descalzo-Navarro, Beatriz Mena-Moros, Elena Damiá, Ángel María Hernández-Guerra, José-María Carrillo, Mónica Rubio and 1 more

Abstract read
In one paragraph

Article in Animals : an open access journal from MDPI, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Emma MartinsBiomed Surgery Group (Bioregenerative Medicine and Applied Surgery), Group School Veterinary Medicine, Universidad Cardenal Herrera-CEU, CEU Universities, C/Tirant lo Blanc, 7, Alfara del Patriarca, 46115 Valencia, Spain.ORCID 0000-0002-8298-9566
Belén CuervoBiomed Surgery Group (Bioregenerative Medicine and Applied Surgery), Group School Veterinary Medicine, Universidad Cardenal Herrera-CEU, CEU Universities, C/Tirant lo Blanc, 7, Alfara del Patriarca, 46115 Valencia, Spain.ORCID 0000-0002-8104-4560
María Gemma Velasco-MartínezBiomed Surgery Group (Bioregenerative Medicine and Applied Surgery), Group School Veterinary Medicine, Universidad Cardenal Herrera-CEU, CEU Universities, C/Tirant lo Blanc, 7, Alfara del Patriarca, 46115 Valencia, Spain.ORCID 0000-0002-0470-9805
Rocío Colomer-SelvaBiomed Surgery Group (Bioregenerative Medicine and Applied Surgery), Group School Veterinary Medicine, Universidad Cardenal Herrera-CEU, CEU Universities, C/Tirant lo Blanc, 7, Alfara del Patriarca, 46115 Valencia, Spain.
María Descalzo-NavarroBiomed Surgery Group (Bioregenerative Medicine and Applied Surgery), Group School Veterinary Medicine, Universidad Cardenal Herrera-CEU, CEU Universities, C/Tirant lo Blanc, 7, Alfara del Patriarca, 46115 Valencia, Spain.ORCID 0009-0003-2269-252X
Beatriz Mena-MorosBiomed Surgery Group (Bioregenerative Medicine and Applied Surgery), Group School Veterinary Medicine, Universidad Cardenal Herrera-CEU, CEU Universities, C/Tirant lo Blanc, 7, Alfara del Patriarca, 46115 Valencia, Spain.ORCID 0009-0000-0587-5031
Elena DamiáBiomed Surgery Group (Bioregenerative Medicine and Applied Surgery), Group School Veterinary Medicine, Universidad Cardenal Herrera-CEU, CEU Universities, C/Tirant lo Blanc, 7, Alfara del Patriarca, 46115 Valencia, Spain.ORCID 0000-0003-2156-9207
Ángel María Hernández-GuerraBiomed Surgery Group (Bioregenerative Medicine and Applied Surgery), Group School Veterinary Medicine, Universidad Cardenal Herrera-CEU, CEU Universities, C/Tirant lo Blanc, 7, Alfara del Patriarca, 46115 Valencia, Spain.ORCID 0000-0002-1771-7214
José-María CarrilloBiomed Surgery Group (Bioregenerative Medicine and Applied Surgery), Group School Veterinary Medicine, Universidad Cardenal Herrera-CEU, CEU Universities, C/Tirant lo Blanc, 7, Alfara del Patriarca, 46115 Valencia, Spain.
Mónica RubioBiomed Surgery Group (Bioregenerative Medicine and Applied Surgery), Group School Veterinary Medicine, Universidad Cardenal Herrera-CEU, CEU Universities, C/Tirant lo Blanc, 7, Alfara del Patriarca, 46115 Valencia, Spain.ORCID 0000-0002-2689-8862
Joaquín SopenaBiomed Surgery Group (Bioregenerative Medicine and Applied Surgery), Group School Veterinary Medicine, Universidad Cardenal Herrera-CEU, CEU Universities, C/Tirant lo Blanc, 7, Alfara del Patriarca, 46115 Valencia, Spain.ORCID 0000-0002-3601-9745

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Osteoarthritis (OA) is the most prevalent degenerative joint disease in both humans and companion animals, causing progressive cartilage destruction for which no curative treatment currently exists. Plasma rich in growth factors (PRGF) has shown chondroprotective effects in veterinary and preclinical models, but its efficacy is limited by the viscosity of synovial fluid and rapid degradation of growth factors within the joint. This study aimed to evaluate the effect of intra-articular co-administration of PRGF and urease-powered enzymatic nanobots on serum biomarkers of inflammation, oxidative stress, and cartilage metabolism in a rabbit (

Indexed as

C2Cchondral defectFRAPhyaluronic acidnanobotsosteoarthritisoxidative stressPRGFrabbit modelurease

Identifiers

PMID42450717
PMCPMC13359658

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.