ReviewBiology2026
Initial Drug Sensitivity and Vulnerability to Substance Use Disorders: A Review of Individual Influences.
Review in Biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Individual differences in the sensitivity and response to drugs of abuse are reliably associated with later patterns of substance use and, for some, progression to a substance use disorder diagnosis. This review synthesizes human drug challenge, longitudinal, and translational animal evidence to characterize how early or initial sensitivity to drugs, shaped by heritable and developmental factors, may relate to subsequent risk. These initial responses, through associative learning, may influence how drug-paired cues acquire motivational significance over time. Ample evidence suggests that early response variability is a biologically grounded and measurable correlate of SUD vulnerability, detectable well before chronic neuroadaptation, with potential utility for targeted prevention and intervention efforts.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.