Evidence map›Paper›PMID 42450608›Full record

ArticleBiology2026

Repeated Humanin Treatment Attenuates Oxidative Stress, Inflammation, and Apoptosis in Diabetic Cardiac Tissue.

Ferah Bulut, Muhammed Adam, Munevver Gizem Hekim, Mete Ozcan

Abstract read
In one paragraph

Article in Biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Ferah BulutDepartment of Biophysics, Faculty of Medicine, Firat University, Elazig TR23119, Turkey.
Muhammed AdamDepartment of Biophysics, Faculty of Medicine, Firat University, Elazig TR23119, Turkey.
Munevver Gizem HekimDepartment of Physiology, Faculty of Medicine, Firat University, Elazig TR23119, Turkey.
Mete OzcanDepartment of Biophysics, Faculty of Medicine, Firat University, Elazig TR23119, Turkey.ORCID 0000-0002-5551-4880

Funding

Fırat University This study received institutional research support from Firat University.The Scientific and Technological Research Council of Türkiye No. 119R084
6 · The paper itself

Abstract

Diabetes mellitus (DM) markedly increases the risk of cardiovascular complications through mechanisms involving hyperglycemia-induced oxidative stress, inflammation, and apoptosis. Humanin (HN), a mitochondria-derived peptide with established cytoprotective properties, has been reported to exert antioxidant and anti-apoptotic effects in several experimental models. However, its role in diabetic cardiac injury remains insufficiently understood. The present study investigated the protective effects of repeated HN treatment against diabetes-induced cardiac injury in a streptozotocin (STZ)-induced mouse model. Mice were divided into four groups: control, HN-treated, STZ-induced diabetic, and STZ + HN-treated groups (

Indexed as

apoptosisdiabetic cardiomyopathyhumanininflammatory cytokinesoxidative stress

Identifiers

PMID42450608
PMCPMC13359586

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.