Evidence map›Paper›PMID 42450371›Full record

ArticleFoods (Basel, Switzerland)2026

A Novel Polysaccharide from Walnut Dregs: Structural Features and Immunomodulatory Effects via Activation of MAPK Signaling Pathway.

Wanying Gong, Min Su, Tianyi Dai, Jinlian Chen, Qianqian Yang, Li Zhang, Wenjing Wang, Weitao Zhang, Jun Sheng, Jing Xie and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Foods (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

11 authors.

Wanying GongCollege of Food Science and Technology, Yunnan Agricultural University, Kunming 650201, China.
Min SuCollege of Food Science and Technology, Yunnan Agricultural University, Kunming 650201, China.
Tianyi DaiCollege of Food Science and Technology, Yunnan Agricultural University, Kunming 650201, China.
Jinlian ChenCollege of Food Science and Technology, Yunnan Agricultural University, Kunming 650201, China.
Qianqian YangCollege of Food Science and Technology, Yunnan Agricultural University, Kunming 650201, China.
Li ZhangCollege of Food Science and Technology, Yunnan Agricultural University, Kunming 650201, China.
Wenjing WangCollege of Food Science and Technology, Yunnan Agricultural University, Kunming 650201, China.
Weitao ZhangCollege of Food Science and Technology, Yunnan Agricultural University, Kunming 650201, China.
Jun ShengCollege of Food Science and Technology, Yunnan Agricultural University, Kunming 650201, China.
Jing XieCollege of Food Science and Technology, Yunnan Agricultural University, Kunming 650201, China.
Yang TianCollege of Food Science and Technology, Yunnan Agricultural University, Kunming 650201, China.

Funding

Yunnan International Joint Laboratory of Green Health Food (China and Thailand) 202203AP140011Yunnan Province-City Integration Project 202302 AN360002Yunnan Province Food and Drug Homologous Resources Functional Food Innovation Team A3032023057Yunnan Province Xing Dian Talent Support Program-Young Talent Special XDYC-QNRC-2023-0405
6 · The paper itself

Abstract

A novel acidic polysaccharide (WDP) was purified from walnut dregs, and its structural characteristics and immunomodulatory function were investigated. WDP had a weight-average molecular weight (Mw) of 351.94 kDa and consisted mainly of rhamnose, arabinose, galactose, glucose, xylose, mannose, galacturonic acid, and glucuronic acid. Methylation and NMR analyses further demonstrated that the backbone of WDP comprised →4)-α-D-GalpA-(1→, →3,6)-β-D-Galp-(1→, →6)-β-D-Galp-(1→, →4)-β-D-Galp-(1→, and →4)-α-D-Glcp-(1→ residues, with branched chains consisting of terminal α-L-Araf-(1→ residues or α-L-Araf-(1→5)-α-L-Araf-(1→ fragments attached to the O-3 position of →3,6)-β-D-Galp-(1→ residues. In vitro assays indicated that WDP modulated immune responses in RAW264.7 cells by enhancing their phagocytosis; increasing NO release and the secretion of IL-1β, IL-6 and TNF-α; and activating the MAPK signaling pathway, suggesting its potential as an immunomodulatory agent. These results provide a scientific foundation for the development of walnut dregs-derived functional foods with immune-enhancing properties.

Indexed as

immunomodulatory activityisolationpolysaccharidepurificationstructural characterizationwalnut dregs

Identifiers

PMID42450371
PMCPMC13361250

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