Evidence map›Paper›PMID 42450337›Full record

ArticleInternational journal of molecular sciences2026

Lipoic Acid Attenuates Lipopolysaccharide- and

Gisela Anay Valencia-Hernández, Mary Fafutis-Morris, Lucila A Godínez-Méndez, Germán Muñoz-Sánchez, Marcela Guadalupe Martínez-Barajas, Andrea A García-Contreras, Liliana Íñiguez-Gutiérrez, Vidal Delgado-Rizo

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Gisela Anay Valencia-HernándezDepartamento de Fisiología, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara 44340, Jalisco, Mexico.
Mary Fafutis-MorrisCentro de Investigación en Inmunología y Dermatología (CIINDE), Universidad de Guadalajara, Zapopan 45190, Jalisco, Mexico.
Lucila A Godínez-MéndezDepartamento de Fisiología, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara 44340, Jalisco, Mexico.ORCID 0000-0002-1631-2370
Germán Muñoz-SánchezDepartamento de Fisiología, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara 44340, Jalisco, Mexico.ORCID 0000-0001-5573-3648
Marcela Guadalupe Martínez-BarajasDepartamento de Microbiología y Patología, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara 44340, Jalisco, Mexico.ORCID 0000-0001-7985-337X
Andrea A García-ContrerasInstituto de Nutrición Humana, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara 44340, Jalisco, Mexico.ORCID 0000-0001-8750-6458
Liliana Íñiguez-GutiérrezDepartamento de Ciencias de la Salud, Centro Universitario de los Valles, Universidad de Guadalajara, Ameca 46600, Jalisco, Mexico.
Vidal Delgado-RizoDepartamento de Fisiología, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara 44340, Jalisco, Mexico.ORCID 0000-0002-2150-6890

Funding

Universidad de Guadalajara PROSNI 2022-2025
6 · The paper itself

Abstract

Neutrophils are essential for antimicrobial defense through reactive oxygen species (ROS) production, tumor necrosis factor-alpha (TNF-α) release, and neutrophil extracellular trap formation. Lipoic acid, a redox-active antioxidant, modulates activation in human neutrophils. Neutrophils isolated from healthy donors were pretreated with lipoic acid and then exposed to lipopolysaccharide (LPS) or whole

Indexed as

Escherichia coliExtracellular TrapsLipopolysaccharidesNeutrophilsReactive Oxygen SpeciesStaphylococcus aureusThioctic AcidHumansTumor Necrosis Factor-alphaLipopolysaccharidesReactive Oxygen SpeciesThioctic AcidTumor Necrosis Factor-alphaalpha-lipoic acidNET formationneutrophilsreactive oxygen speciesTNF-alpha

Identifiers

PMID42450337
PMCPMC13362040

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.