Evidence map›Paper›PMID 42450315›Full record

ArticleInternational journal of molecular sciences2026

Bacterial-Derived Signals Selectively Remodel Glycosaminoglycan Biosynthetic Pathways in Reconstructed Human Corneal Epithelium.

Noelia Blanco-Agudín, Natalia Vázquez, Suhui Ye, Cristina Sánchez-Fernández, Iván Fernández-Vega, Álvaro Meana, Jesús Merayo-Lloves, Luis M Quirós

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Noelia Blanco-AgudínInstituto Universitario Fernández-Vega (IUFV), Fundación de Investigación Oftalmológica, 33006 Oviedo, Spain.ORCID 0000-0002-0744-0493
Natalia VázquezInstituto Universitario Fernández-Vega (IUFV), Fundación de Investigación Oftalmológica, 33006 Oviedo, Spain.ORCID 0000-0002-3410-2190
Suhui YeInstituto Universitario Fernández-Vega (IUFV), Fundación de Investigación Oftalmológica, 33006 Oviedo, Spain.ORCID 0000-0002-4466-4242
Cristina Sánchez-FernándezInstituto Universitario Fernández-Vega (IUFV), Fundación de Investigación Oftalmológica, 33006 Oviedo, Spain.ORCID 0000-0001-6658-2590
Iván Fernández-VegaInstituto Universitario Fernández-Vega (IUFV), Fundación de Investigación Oftalmológica, 33006 Oviedo, Spain.ORCID 0000-0002-3141-6493
Álvaro MeanaInstituto Universitario Fernández-Vega (IUFV), Fundación de Investigación Oftalmológica, 33006 Oviedo, Spain.ORCID 0000-0001-9434-6042
Jesús Merayo-LlovesInstituto Universitario Fernández-Vega (IUFV), Fundación de Investigación Oftalmológica, 33006 Oviedo, Spain.
Luis M QuirósInstituto Universitario Fernández-Vega (IUFV), Fundación de Investigación Oftalmológica, 33006 Oviedo, Spain.ORCID 0000-0003-3505-3762

Funding

Gobierno del Principado de Asturias SEK-25-GRU-GIC-24-069Instituto de Salud Carlos III PI22/01240Ministerio de Universidades FPU20/06016Ministerio de Universidades MCINN-23-PLEC2022-009463
6 · The paper itself

Abstract

Proteoglycans (PGs) and their glycosaminoglycan (GAG) chains play key roles in corneal epithelial physiology and host-microbe interactions. Although bacterial exposure has been shown to alter PG and GAG biosynthesis, the contribution of specific bacterial-derived signals remains unclear. In this study, reconstructed human corneal epithelia (QobuR) were exposed to bacterial extracellular vesicles (BEVs) from

Indexed as

Biosynthetic PathwaysEpithelium, CornealGlycosaminoglycansChondroitin SulfatesHeparan SulfateHumansLipopolysaccharidesPeptidoglycanPseudomonas aeruginosaStaphylococcus epidermidisSulfotransferasesTeichoic AcidsChondroitin SulfatesGlycosaminoglycansHeparan SulfateLipopolysaccharideslipoteichoic acidPeptidoglycanSulfotransferasesTeichoic Acidsbacterial extracellular vesiclescorneal epitheliumglycosaminoglycansheparan sulfatehost–microbe interactionsmicrobial-associated molecular patterns

Identifiers

PMID42450315
PMCPMC13361807

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.