ArticleInternational journal of molecular sciences2026
Cartilage Oligomeric Matrix Protein (COMP) Correlates with Disease Progression, Selected Immune Checkpoint Molecules and SIGLEC9 in Colorectal Cancer.
Piotr Limanówka, Anna Kot, Wiktor Wagner, Błażej Ochman, Sylwia Mielcarska, Agnieszka Kula, Miriam Dawidowicz, Dorota Hudy, Monika Szrot, Jerzy Piecuch and 4 more
Abstract read
In one paragraphArticle in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
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3 · Its place in the literatureWho cites it
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
14 authors.
Piotr LimanówkaDepartment of Medical and Molecular Biology, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, 41-808 Zabrze, Poland.ORCID 0009-0006-0323-4357 Anna KotDepartment of Medical and Molecular Biology, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, 41-808 Zabrze, Poland.
Wiktor WagnerDepartment of Medical and Molecular Biology, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, 41-808 Zabrze, Poland.ORCID 0009-0000-6909-7523 Błażej OchmanDepartment of Medical and Molecular Biology, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, 41-808 Zabrze, Poland.
Sylwia MielcarskaDepartment of Medical and Molecular Biology, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, 41-808 Zabrze, Poland.
Agnieszka KulaDepartment of Oncological Surgery, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, 41-808 Katowice, Poland.
Miriam DawidowiczDepartment of Oncological Surgery, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, 41-808 Katowice, Poland.
Dorota HudyDepartment of Medical and Molecular Biology, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, 41-808 Zabrze, Poland.ORCID 0000-0002-9110-2314 Monika SzrotDepartment of General and Bariatric Surgery and Emergency Medicine in Zabrze, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, 41-800 Zabrze, Poland.
Jerzy PiecuchDepartment of General and Bariatric Surgery and Emergency Medicine in Zabrze, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, 41-800 Zabrze, Poland.
Zenon CzubaDepartment of Microbiology and Immunology, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, 41-808 Zabrze, Poland.ORCID 0000-0001-8216-4495 Elżbieta ŚwiętochowskaDepartment of Medical and Molecular Biology, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, 41-808 Zabrze, Poland.
Iwona Gisterek-GrocholskaDepartment of Oncology and Radiotherapy, Medical University of Silesia, 40-615 Katowice, Poland.ORCID 0000-0002-6320-0224 Dariusz WaniczekDepartment of Oncological Surgery, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, 41-808 Katowice, Poland.ORCID 0000-0002-0410-8604 Funding
Medical University of Silesia Statutory fundsMinistry of Science and Higher Education SKN/SP/496435/2021Ministry of Science and Higher Education SKN/SP/570127/2023Silesian Voivodeship Metropolitan Fund for Science Support
6 · The paper itselfAbstract
Cartilage oligomeric matrix protein (COMP) influences extracellular matrix remodeling. We investigated its clinical, prognostic, and immunomodulatory significance in colorectal cancer (CRC). COMP was quantified via ELISA in 107 paired CRC and normal tissues. Expression was correlated with clinicopathological features, mutational profiles, microsatellite instability (MSI), tumor-infiltrating lymphocytes (TILs), immune checkpoints, and multiplex cytokine networks. For transcriptomic validation, the FieldEffectCrc dataset was used for Gene Set Enrichment Analysis (GSEA), and The Cancer Genome Atlas (TCGA) CRC cohort for survival analysis. COMP was significantly upregulated in CRC tissues (
Indexed as
Cartilage Oligomeric Matrix ProteinColorectal NeoplasmsImmune Checkpoint ProteinsLectinsBiomarkers, TumorDisease ProgressionFemaleGalectinsGene Expression Regulation, NeoplasticHepatitis A Virus Cellular Receptor 2HumansLymphocytes, Tumor-InfiltratingMaleMicrosatellite InstabilityPrognosisTumor MicroenvironmentBiomarkers, TumorCartilage Oligomeric Matrix ProteinGalectinsHAVCR2 protein, humanHepatitis A Virus Cellular Receptor 2Immune Checkpoint ProteinsLectinsLGALS9 protein, humanTSP5 protein, humancartilage oligomeric matrix proteincolorectal cancergalectin 9SIGLEC9TIM-3tumor-infiltrating lymphocytestumor microenvironment
Identifiers
PMID42450298
PMCPMC13362197
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