Evidence map›Paper›PMID 42450285›Full record

ArticleInternational journal of molecular sciences2026

Uromodulin: A Novel Regulator of the Kidney-Adipose Axis in Diabetic Kidney Disease.

Linan Cheng, Zheyu Xing, Di Song, Nan Hu, Chunyue Wang, Yuqing Chen

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Linan ChengRenal Division, Peking University First Hospital, No. 8, Xishiku Street, Xicheng District, Beijing 100034, China.
Zheyu XingRenal Division, Peking University First Hospital, No. 8, Xishiku Street, Xicheng District, Beijing 100034, China.
Di SongRenal Division, Peking University First Hospital, No. 8, Xishiku Street, Xicheng District, Beijing 100034, China.
Nan HuRenal Division, Peking University First Hospital, No. 8, Xishiku Street, Xicheng District, Beijing 100034, China.
Chunyue WangRenal Division, Peking University First Hospital, No. 8, Xishiku Street, Xicheng District, Beijing 100034, China.
Yuqing ChenRenal Division, Peking University First Hospital, No. 8, Xishiku Street, Xicheng District, Beijing 100034, China.ORCID 0000-0001-7857-3106

Funding

National High-Level Hospital Clinical Research Funding 2022CX13National Natural Science Foundation of China 82070749
6 · The paper itself

Abstract

The rising burden of diabetic kidney disease (DKD) and its associated lipid abnormalities underscores the need for new mechanistic insights. Uromodulin, a kidney-enriched protein, has been associated with metabolic disorders in human studies, yet its functional role in systemic lipid metabolism remains elusive. In this study, transcriptomic datasets were analyzed to investigate uromodulin expression and biological function in DKD. Subsequently, a diabetic model was induced in

Indexed as

Adipose TissueDiabetes Mellitus, ExperimentalDiabetic NephropathiesKidneyUromodulinAnimalsDiet, High-FatLipid MetabolismMaleRatsUromodulindiabetic kidney diseaselipodystrophy-like phenotypeuromodulin

Identifiers

PMID42450285
PMCPMC13360967

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.