ArticleInternational journal of molecular sciences2026
Serum EV-Derived rno-let-7b-5p Is Associated with Lung-Adipose Alterations in Allergic Asthma.
Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Extracellular vesicles (EVs) and their miRNA cargo are important regulators of intercellular communication, but their role in connecting respiratory inflammation in asthma with systemic metabolic alterations remains unclear. We hypothesized that HDM-induced allergic inflammation alters selected serum EV-derived miRNAs and that these changes are associated with molecular alterations in lung and adipose tissue. Serum EV-miRNAs from control and HDM-induced allergic rats were isolated by size-exclusion chromatography and analyzed using TaqMan Advanced miRNA Assays. Candidate rno-let-7b-5p targets were integrated with lung and adipose tissue microarray data, validated by qPCR, and assessed in silico using IntaRNA and DMISO. Among the 13 analyzed miRNAs, rno-let-7b-5p showed a nominally significant 1.5-fold increase in serum EVs from allergic rats (unadjusted
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