Evidence map›Paper›PMID 42450227›Full record

ArticleInternational journal of molecular sciences2026

HMGB1 Upregulates MMP-1-Mediated Mesothelial-Mesenchymal Transition and Promotes Pleural Fibrosis in Tuberculous Pleural Effusion.

Wei-Lin Chen, Kai-Ling Lee, Mei-Chuan Chen, Shih-Hsin Hsiao, Chi-Li Chung

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Wei-Lin ChenDepartment of Nursing, MacKay Junior College of Medicine, Nursing, and Management, Taipei 112, Taiwan.
Kai-Ling LeeDivision of Pulmonary Medicine, Department of Internal Medicine, Taipei Medical University Hospital, Taipei 110, Taiwan.ORCID 0000-0001-9597-1413
Mei-Chuan ChenGraduate Institute of Clinical Medicine, College of Medicine, Taipei Medical University, Taipei 110, Taiwan.
Shih-Hsin HsiaoDivision of Pulmonary Medicine, Department of Internal Medicine, Taipei Medical University Hospital, Taipei 110, Taiwan.
Chi-Li ChungDivision of Pulmonary Medicine, Department of Internal Medicine, Taipei Medical University Hospital, Taipei 110, Taiwan.ORCID 0000-0003-0656-976X

Funding

Mackay Junior College of Medicine, Nursing and Management MKC 113R02
6 · The paper itself

Abstract

High-mobility group box 1 (HMGB1) has been implicated in matrix remodeling and fibrotic disorders; however, its role in tuberculosis (TB)-associated pleural fibrosis remains unknown. Pleural fluid levels of HMGB1 and matrix metalloproteinase-1 (MMP-1) in patients with TB pleural effusion (TBPE,

Indexed as

Epithelial-Mesenchymal TransitionHMGB1 ProteinMatrix Metalloproteinase 1Pleural EffusionTuberculosis, PleuralAdultAgedFemaleFibrosisHumansMaleMiddle AgedMycobacterium tuberculosisPleuraUp-RegulationHMGB1 ProteinHMGB1 protein, humanMatrix Metalloproteinase 1MMP1 protein, humanhigh mobility group box 1 proteinJNK/AP-1 signalingmatrix metalloproteinase-1mesothelial-to-mesenchymal transitionpleural fibrosispleural mesothelial celltuberculous pleural effusion

Identifiers

PMID42450227
PMCPMC13362252

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.