Evidence map›Paper›PMID 42450175›Full record

ArticleInternational journal of molecular sciences2026

Interferon Receptor Chain Deficiency in Murine Friend Erythroleukemia Cell Clone Resistant to Type I or Type I and II Interferons.

Zulema Antonia Percario, Giorgio Mangino, Arianna Raponi, Emiliano Fratini, Gabriele Vaccari, Flavia Giannessi, Gianna Fiorucci, Manuela Cervelli, Giovanna Romeo, Elisabetta Affabris

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Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Zulema Antonia PercarioDepartment of Science, Roma Tre University, 00146 Rome, Italy.
Giorgio ManginoDepartment of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome, 04100 Latina, Italy.ORCID 0000-0002-8950-9780
Arianna RaponiDepartment of Science, Roma Tre University, 00146 Rome, Italy.ORCID 0000-0003-4698-7552
Emiliano FratiniLaboratory of Red Biotechnologies, Italian National Agency for New Technologies, Energy and Sustainable Economic Development (ENEA), Casaccia Research Centre, 00123 Rome, Italy.ORCID 0000-0003-2522-1718
Gabriele VaccariDepartment of Food Safety and Veterinary Public Health, Istituto Superiore di Sanità, 00161 Rome, Italy.ORCID 0000-0003-0215-3521
Flavia GiannessiDepartment of Science, Roma Tre University, 00146 Rome, Italy.
Gianna FiorucciInstitute of Molecular Biology and Pathology, Consiglio Nazionale delle Ricerche, 00185 Rome, Italy.
Manuela CervelliDepartment of Science, Roma Tre University, 00146 Rome, Italy.ORCID 0000-0001-8535-8279
Giovanna RomeoDepartment of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome, 04100 Latina, Italy.ORCID 0000-0002-7638-1001
Elisabetta AffabrisDepartment of Science, Roma Tre University, 00146 Rome, Italy.ORCID 0000-0001-5142-8144

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Interferon (IFN)-resistant cell clones 3Cl8 and 3γR8, isolated from wild-type Friend erythroleukemia cells 745A were characterized to identify the resistance defect. The 3Cl8 cell clone is resistant to type I IFNs and sensitive to type II IFN, whereas 3γR8, derived from 3Cl8, is resistant to both type I and II IFNs. Here, we report that no activation of the JAK-STAT pathway is detected after IFN treatment of resistant cells. Interestingly, the absence of major transcripts of the IFNAR2 receptor chain has been observed in type I IFN-resistant cells, and a point mutation relative to the IFNGR2 receptor chain (β chain) has been identified in type II IFN-resistant cells, inducing a frameshift leading to premature termination of translation. In addition, we have identified a new polymorphism of the murine IFNAR1 chain and possibly the presence of a murine IFNAR2b transmembrane, non-transducing chain in 745A cells, similar to that observed in humans and differing from previous reports on other murine systems.

Indexed as

Drug Resistance, NeoplasmInterferon-gammaInterferon Type ILeukemia, Erythroblastic, AcuteReceptor, Interferon alpha-betaReceptors, InterferonAnimalsCell Line, TumorFriend murine leukemia virusMiceSignal TransductionInterferon-gammaInterferon Type IReceptor, Interferon alpha-betaReceptors, InterferonFriend erythroleukemia cellsFriend erythroleukemia virusmurine IFNARmurine IFNGRmurine retrovirustype I IFNtype I IFN receptorstype II IFNtype II IFN receptor

Identifiers

PMID42450175
PMCPMC13360625

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.