Bakuchiol Enhances 5-Fluorouracil Efficacy in Colorectal Cancer Cells via a ROS-Dependent Mechanism Involving Mitochondrial Dysfunction and Apoptosis.

Dominika Radomska, Olga Szewczyk-Roszczenko, Magda Chalecka, Arkadiusz Surazynski, Anna Szymanowska, Krzysztof Bielawski, Robert Czarnomysy

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Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Dominika RadomskaDepartment of Synthesis and Technology of Drugs, Medical University of Bialystok, Kilinskiego 1, 15-089 Bialystok, Poland.ORCID 0000-0002-4747-0312

Olga Szewczyk-RoszczenkoDepartment of Synthesis and Technology of Drugs, Medical University of Bialystok, Kilinskiego 1, 15-089 Bialystok, Poland.

Magda ChaleckaDepartment of Medicinal Chemistry, Medical University of Bialystok, Mickiewicza 2D, 15-222 Bialystok, Poland.

Arkadiusz SurazynskiDepartment of Medicinal Chemistry, Medical University of Bialystok, Mickiewicza 2D, 15-222 Bialystok, Poland.ORCID 0000-0003-4475-873X

Anna SzymanowskaDepartment of Synthesis and Technology of Drugs, Medical University of Bialystok, Kilinskiego 1, 15-089 Bialystok, Poland.ORCID 0000-0003-4783-3336

Krzysztof BielawskiDepartment of Synthesis and Technology of Drugs, Medical University of Bialystok, Kilinskiego 1, 15-089 Bialystok, Poland.ORCID 0000-0003-3187-4205

Robert CzarnomysyDepartment of Synthesis and Technology of Drugs, Medical University of Bialystok, Kilinskiego 1, 15-089 Bialystok, Poland.ORCID 0000-0002-7148-6111

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Resistance to 5-fluorouracil (5-FU) remains a major limitation in colorectal cancer therapy, prompting the development of combination strategies aimed at improving its efficacy. Bakuchiol (BAK), a natural compound with reported antioxidant and pro-oxidant properties, may modulate redox balance and enhance chemotherapy response. This study compared the effects of 5-FU and BAK, applied as monotherapies and in combination, in DLD-1 and HT-29 colorectal cancer cells. Cytotoxicity assays showed that co-treatment significantly reduced the IC

Indexed as

ApoptosisColorectal NeoplasmsFluorouracilMitochondriaPhenolsReactive Oxygen SpeciesCell Line, TumorDrug SynergismHT29 CellsHumansMembrane Potential, MitochondrialOxidative StressbakuchiolFluorouracilPhenolsReactive Oxygen Species5-FUanticancer activitybakuchiolcancer co-treatmentcancer therapychemotherapycolorectal cancercombination therapynatural compounds

Identifiers

PMID42450164

DOI10.3390/ijms27135894

PMCPMC13361224

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LicenceCC BY

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.