Evidence map›Paper›PMID 42450134›Full record

ArticleInternational journal of molecular sciences2026

The Role of Polymer Encapsulation in Optimizing Donor-Acceptor Organic Nanoparticles for Efficient Cancer Phototherapy.

Yulia A Isaeva, Dmitry O Balakirev, Anastasia A Vetyugova, Maxim E Stepanov, Michael D Khitrov, Nikita S Saratovsky, Mikhail V Zolotov, Tatyana V Egorova, Polina A Demina, Roman A Akasov and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Yulia A IsaevaEnikolopov Institute of Synthetic Polymeric Materials of the Russian Academy of Sciences, Profsoyuznaya St. 70, Moscow 117393, Russia.
Dmitry O BalakirevEnikolopov Institute of Synthetic Polymeric Materials of the Russian Academy of Sciences, Profsoyuznaya St. 70, Moscow 117393, Russia.ORCID 0000-0003-4714-8822
Anastasia A VetyugovaEnikolopov Institute of Synthetic Polymeric Materials of the Russian Academy of Sciences, Profsoyuznaya St. 70, Moscow 117393, Russia.
Maxim E StepanovInstitute of Physics, Technology and Information Systems, Moscow Pedagogical State University, Malaya Pirogovskaya St. 29/7, Building 1, Moscow 119991, Russia.
Michael D KhitrovEnikolopov Institute of Synthetic Polymeric Materials of the Russian Academy of Sciences, Profsoyuznaya St. 70, Moscow 117393, Russia.ORCID 0000-0003-3005-8302
Nikita S SaratovskyEnikolopov Institute of Synthetic Polymeric Materials of the Russian Academy of Sciences, Profsoyuznaya St. 70, Moscow 117393, Russia.
Mikhail V ZolotovEnikolopov Institute of Synthetic Polymeric Materials of the Russian Academy of Sciences, Profsoyuznaya St. 70, Moscow 117393, Russia.
Tatyana V EgorovaEnikolopov Institute of Synthetic Polymeric Materials of the Russian Academy of Sciences, Profsoyuznaya St. 70, Moscow 117393, Russia.
Polina A DeminaPetrovsky National Research Center of Surgery, Moscow 119991, Russia.ORCID 0000-0001-6349-2979
Roman A AkasovEnikolopov Institute of Synthetic Polymeric Materials of the Russian Academy of Sciences, Profsoyuznaya St. 70, Moscow 117393, Russia.ORCID 0000-0001-6486-8114
Yuriy N LuponosovEnikolopov Institute of Synthetic Polymeric Materials of the Russian Academy of Sciences, Profsoyuznaya St. 70, Moscow 117393, Russia.ORCID 0000-0002-3701-2123

Funding

Russian Science Foundation 25-13-00422
6 · The paper itself

Abstract

Donor-acceptor (D-A) molecular systems are gaining increasing attention in cancer imaging and phototherapy due to their tunable optical properties and high photosensitizing efficiency. Encapsulation of such D-A molecules in nano-sized polymeric carriers can enhance the efficiency of antitumor therapy by passive tumor accumulation and controlled drug release. Here, we synthesized two D-A molecules-TTDCV and TTInd-based on triphenylamine with thiophene π-spacers and electron-withdrawing dicyanovinyl or indene-1,3-dione moieties. These molecules were used to preparate nanoparticles (NPs) via nanoprecipitation with amphiphilic polymers-poly(ethylene glycol)-block polylactide methyl ether (PEG-b-PLA) and polyethylene oxide-polypropylene oxide (PEO-PPO-PEO, Pluronic

Indexed as

NanoparticlesPhotosensitizing AgentsPhototherapyPolymersCell Line, TumorHumansMCF-7 CellsPoloxamerPolyethylene GlycolsPropylene GlycolsReactive Oxygen SpeciesPhotosensitizing AgentsPoloxamerPolyethylene GlycolsPolymersPropylene GlycolsReactive Oxygen Speciesdonor–acceptor moleculesencapsulationnanoparticlesorganic dyesphotodynamic therapyphotothermal therapy

Identifiers

PMID42450134
PMCPMC13361513

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.