Evidence map›Paper›PMID 42450118›Full record

ArticleInternational journal of molecular sciences2026

Targeting Periodontitis with Treg-Derived Extracellular Vesicles: Modulation of Macrophages and CD8

Carolina Rojas, Luis González-Osuna, Michelle García, Alfredo Sierra-Cristancho, Luis Daniel Sansores-España, Paola Carvajal, Lesley A Smyth, Karina Pino-Lagos, Rolando Vernal

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Carolina RojasPeriodontal Biology Laboratory, Faculty of Dentistry, Universidad de Chile, Santiago 8380544, Chile.ORCID 0000-0003-4004-3999
Luis González-OsunaPeriodontal Biology Laboratory, Faculty of Dentistry, Universidad de Chile, Santiago 8380544, Chile.ORCID 0000-0002-8456-6372
Michelle GarcíaPeriodontal Biology Laboratory, Faculty of Dentistry, Universidad de Chile, Santiago 8380544, Chile.ORCID 0000-0002-4283-7269
Alfredo Sierra-CristanchoPeriodontal Biology Laboratory, Faculty of Dentistry, Universidad de Chile, Santiago 8380544, Chile.ORCID 0000-0003-0952-9835
Luis Daniel Sansores-EspañaPeriodontal Biology Laboratory, Faculty of Dentistry, Universidad de Chile, Santiago 8380544, Chile.
Paola CarvajalPeriodontal Biology Laboratory, Faculty of Dentistry, Universidad de Chile, Santiago 8380544, Chile.
Lesley A SmythSchool of Medicine and Biomedical Sciences, University of West London, London W5 5RF, UK.
Karina Pino-LagosBiomedical Research and Innovation Center, Faculty of Medicine, Universidad de Los Andes, Santiago 7620086, Chile.ORCID 0000-0002-4070-6169
Rolando VernalPeriodontal Biology Laboratory, Faculty of Dentistry, Universidad de Chile, Santiago 8380544, Chile.ORCID 0000-0002-1391-320X

Funding

National Agency for Research and Development Fondecyt 1220999
6 · The paper itself

Abstract

Periodontitis is a chronic inflammatory disease characterized by alveolar bone loss driven by dysregulated immune responses. We previously showed that extracellular vesicles derived from retinoic acid-induced regulatory T lymphocytes (RA-Treg EVs) suppress pathogenic CD4

Indexed as

CD8-Positive T-LymphocytesExtracellular VesiclesMacrophagesPeriodontitisT-Lymphocytes, RegulatoryAlveolar Bone LossAnimalsMaleMiceMice, Inbred C57BLalveolar bone lossCD8+ T lymphocytesextracellular vesiclesmacrophagesperiodontitisregulatory T cellTreg

Identifiers

PMID42450118
PMCPMC13362477

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.