Evidence map›Paper›PMID 42450094›Full record

ArticleInternational journal of molecular sciences2026

Immune Regulatory Endotypes Defined by TRIM-Dependent Ubiquitin Signaling and IFN-NF-κB Network Activity in Ankylosing Spondylitis.

Sevil Ceyhan Dogan, Tugba Agbektas, Mert Atas, Gonca Kabak, Ayca Tas, Yavuz Silig

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Sevil Ceyhan DoganDepartment of Physical Medicine and Rehabilitation, Faculty of Medicine, Sivas Cumhuriyet University, Sivas 58140, Turkey.ORCID 0000-0003-1570-8848
Tugba AgbektasDepartment of Food Processing Technologies, Yıldızeli Vocational School, Sivas Cumhuriyet University, Sivas 58140, Turkey.
Mert AtasDepartment of Physical Medicine and Rehabilitation, Faculty of Medicine, Sivas Cumhuriyet University, Sivas 58140, Turkey.ORCID 0000-0002-6713-5888
Gonca KabakDepartment of Medical Biochemistry, Faculty of Medicine, Sivas Cumhuriyet University, Sivas 58140, Turkey.
Ayca TasDepartment of Medical Biochemistry, Faculty of Medicine, Sivas Cumhuriyet University, Sivas 58140, Turkey.ORCID 0000-0002-7132-1325
Yavuz SiligDepartment of Medical Biochemistry, Faculty of Medicine, Sivas Cumhuriyet University, Sivas 58140, Turkey.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ankylosing Spondylitis (AS) is a chronic inflammatory autoimmune rheumatic disease that primarily affects the spine and sacroiliac joints. This study aimed to investigate the expression levels of immune response-related genes, including

Indexed as

InterferonsNF-kappa BSignal TransductionSpondylitis, AnkylosingTripartite Motif ProteinsUbiquitinAdultBiomarkersCase-Control StudiesChemokine CXCL10FemaleGene Expression RegulationHumansMaleMiddle AgedMinor Histocompatibility AntigensBiomarkersChemokine CXCL10CXCL10 protein, humanInterferonsMinor Histocompatibility AntigensNF-kappa BReceptors, ImmunologicRepressor ProteinsTranscription FactorsTRIM21 ProteinTRIM22 protein, humanTRIM25 protein, humanTripartite Motif ProteinsUbiquitinUbiquitin-Protein Ligasesankylosing spondylitisinterferon signalingNF-κB signalingTRIM genes

Identifiers

PMID42450094
PMCPMC13361498

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.