Fenfluramine Attenuates Retinal Microglial Activation but Does Not Rescue Structural and Vascular Deficits in a Rat Model of Dravet Syndrome.

Yajuan Zhang, Weixin Qian, Miao Li, Ying-Ying Zou, Zhonghua Lu, Zhihui Huang, Robert K Naumann, Hong Wang

Abstract read

In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yajuan ZhangSchool of Pharmacy, Hangzhou Normal University, Hangzhou 311121, China.ORCID 0009-0005-5840-7094

Weixin QianThe Institute of Biomedical and Health Engineering, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, 1068 Xueyuan Blvd, Shenzhen 230027, China.ORCID 0009-0008-7070-2653

Miao LiThe Institute of Biomedical and Health Engineering, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, 1068 Xueyuan Blvd, Shenzhen 230027, China.

Ying-Ying ZouDepartment of Pathology and Pathophysiology, Faculty of Basic Medical Sciences, Kunming Medical University, Kunming 650500, China.

Zhonghua LuThe Institute of Biomedical and Health Engineering, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, 1068 Xueyuan Blvd, Shenzhen 230027, China.ORCID 0000-0002-7102-5956

Zhihui HuangSchool of Pharmacy, Hangzhou Normal University, Hangzhou 311121, China.

Robert K NaumannThe Institute of Biomedical and Health Engineering, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, 1068 Xueyuan Blvd, Shenzhen 230027, China.

Hong WangSchool of Pharmacy, Hangzhou Normal University, Hangzhou 311121, China.

Funding

National Science and Technology Major Project 2022ZD0211700People's Government of Guangdong Province Guangdong Foreign Talents Program (2025A1313010088)

6 · The paper itself

Abstract

Dravet syndrome (DS) is a severe developmental and epileptic encephalopathy caused by

Indexed as

Epilepsies, MyoclonicFenfluramineMicrogliaRetinaAnimalsDisease Models, AnimalElectroretinographyMaleNAV1.1 Voltage-Gated Sodium ChannelRatsRetinal VesselsFenfluramineNAV1.1 Voltage-Gated Sodium ChannelDravet syndromeelectroretinographfenfluraminemicrogliaretina

Identifiers

PMID42450024

DOI10.3390/ijms27135752

PMCPMC13361747

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.