Evidence map›Paper›PMID 42450016›Full record

ArticleInternational journal of molecular sciences2026

In Silico Identification of Conserved 'Fungal Islands' in Human Septin9: Evidence for Atavistic Therapeutic Targets.

Ömer Eren Özcan, Ayhan Bilir, Berna Yıldırım

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Ömer Eren ÖzcanFaculty of Medicine, Istanbul Atlas University, Istanbul 34403, Turkey.ORCID 0009-0007-7359-6449
Ayhan BilirDepartment of Histology and Embryology, Faculty of Medicine, Istanbul Atlas University, Istanbul 34403, Turkey.ORCID 0009-0009-9399-5927
Berna YıldırımDepartment of Histology and Embryology, Faculty of Medicine, Istanbul Atlas University, Istanbul 34403, Turkey.ORCID 0000-0002-4479-2586

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Metastasis, the primary cause of cancer mortality, relies on malignant cells acquiring extreme mobility and mechanical plasticity. We posit that this physical transition is driven not by de novo genetic innovations but by an atavistic reversion to highly conserved cytoskeletal blueprints, termed "Fungal Islands." Through in silico sequence alignments and molecular docking, we investigated structural homology between human septin-9 (

Indexed as

SeptinsAmino Acid SequenceCell Cycle ProteinsComputer SimulationConserved SequenceEvolution, MolecularHumansMolecular Docking SimulationSaccharomyces cerevisiae ProteinsSequence AlignmentCell Cycle ProteinsSaccharomyces cerevisiae ProteinsSEPTIN9 protein, humanSeptinsatavistic theorycancer metastasisfungal islandsSeptin-9

Identifiers

PMID42450016
PMCPMC13362331

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.