Survivin Associates with VDAC2 and Bcl2-Family Proteins at the Mitochondrial Outer Membrane.

Adesh D Vaidya, Hilmi Arica, Hana Abdelkabir, Lolwah Alsalamah, Kirstie Coe, Sally P Wheatley

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In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed

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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Adesh D VaidyaSchool of Life Sciences, University of Nottingham, Nottingham NG7 2UH, UK.ORCID 0009-0008-5387-0575

Hilmi AricaSchool of Life Sciences, University of Nottingham, Nottingham NG7 2UH, UK.

Hana AbdelkabirSchool of Life Sciences, University of Nottingham, Nottingham NG7 2UH, UK.

Lolwah AlsalamahSchool of Life Sciences, University of Nottingham, Nottingham NG7 2UH, UK.ORCID 0000-0002-2098-2916

Kirstie CoeSchool of Life Sciences, University of Nottingham, Nottingham NG7 2UH, UK.

Sally P WheatleySchool of Life Sciences, University of Nottingham, Nottingham NG7 2UH, UK.ORCID 0000-0002-9550-8979

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Survivin is a cancer-associated inhibitor of apoptosis protein (IAP) that can suppress both extrinsic and intrinsic apoptotic pathways. IAPs typically prevent programmed cell death by binding to caspases, but whether survivin behaves as a canonical IAP or can protect cells from death by alternative means has not been fully investigated. Here, we report a novel interaction between survivin and the mitochondrial outer membrane protein, VDAC2, which we show is an indirect association potentially mediated by Bcl2-family members. This novel finding suggests survivin can suppress mitochondrial-mediated apoptosis upstream of caspases and could open a new avenue for targeting survivin in anti-cancer therapy regimes.

Indexed as

Inhibitor of Apoptosis ProteinsMitochondrial MembranesProto-Oncogene Proteins c-bcl-2Voltage-Dependent Anion Channel 2ApoptosisHumansMitochondriaProtein BindingSurvivinBIRC5 protein, humanInhibitor of Apoptosis ProteinsProto-Oncogene Proteins c-bcl-2SurvivinVDAC2 protein, humanVoltage-Dependent Anion Channel 2apoptosisBakBaxBcl2-familyBcl-XLmitochondriaporinsurvivinVDAC

Identifiers

PMID42449981

DOI10.3390/ijms27135707

PMCPMC13362165

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LicenceCC BY

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.