Evidence map›Paper›PMID 42449964›Full record

ArticleInternational journal of molecular sciences2026

Transcriptional Cytokine Responses Linked to Pathological Outcomes in Broiler Chickens Fed Residual Doses of Antimicrobials.

Anna Slawinska, Joanna Bogucka, Aleksandra Dunislawska, Sebastian Knaga, Maria Siwek, Agnieszka Chłodowska, Monika Olszewska-Tomczyk, Malgorzata Olejnik

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Anna SlawinskaDepartment of Basic and Preclinical Sciences, Institute of Veterinary Medicine, Faculty of Biological and Veterinary Sciences, Nicolaus Copernicus University, Szosa Bydgoska 13, 87-100 Toruń, Poland.ORCID 0000-0002-5706-6145
Joanna BoguckaDepartment of Basic and Preclinical Sciences, Institute of Veterinary Medicine, Faculty of Biological and Veterinary Sciences, Nicolaus Copernicus University, Szosa Bydgoska 13, 87-100 Toruń, Poland.ORCID 0000-0001-5298-1144
Aleksandra DunislawskaDepartment of Animal Biotechnology and Genetics, Faculty of Animal Breeding and Biology, Bydgoszcz University of Science and Technology, Mazowiecka 28, 85-084 Bydgoszcz, Poland.ORCID 0000-0001-6608-0013
Sebastian KnagaDepartment of Animal Biotechnology and Genetics, Faculty of Animal Breeding and Biology, Bydgoszcz University of Science and Technology, Mazowiecka 28, 85-084 Bydgoszcz, Poland.ORCID 0000-0002-7176-3000
Maria SiwekDepartment of Animal Biotechnology and Genetics, Faculty of Animal Breeding and Biology, Bydgoszcz University of Science and Technology, Mazowiecka 28, 85-084 Bydgoszcz, Poland.ORCID 0000-0003-4148-5174
Agnieszka ChłodowskaDepartment of Basic and Preclinical Sciences, Institute of Veterinary Medicine, Faculty of Biological and Veterinary Sciences, Nicolaus Copernicus University, Szosa Bydgoska 13, 87-100 Toruń, Poland.
Monika Olszewska-TomczykDepartment of Infectious and Invasive Diseases and Veterinary Administration, Institute of Veterinary Medicine, Faculty of Biological and Veterinary Sciences, Nicolaus Copernicus University, Szosa Bydgoska 13, 87-100 Toruń, Poland.ORCID 0000-0001-9188-3950
Malgorzata OlejnikDepartment of Basic and Preclinical Sciences, Institute of Veterinary Medicine, Faculty of Biological and Veterinary Sciences, Nicolaus Copernicus University, Szosa Bydgoska 13, 87-100 Toruń, Poland.ORCID 0000-0003-2106-2473

Funding

National Science Centre 2021/41/B/NZ9/04114
6 · The paper itself

Abstract

Cross-contamination of poultry feed with antimicrobials may cause unintended exposure to residual antibiotic doses, but the immunological consequences remain unclear. We tested whether six antimicrobials (colistin, doxycycline, flumequine, thiamphenicol, tiamulin, and tilmicosin) delivered in feed at 2% of the maximum approved dose modulate immune-related gene expression and splenic histology in broiler chickens. Female Ross 308 chicks received antibiotic-contaminated diets throughout the rearing. Spleen and caecal mucosa were sampled on days 7, 21, and 35, and analyzed by RT-qPCR. Spleen was sampled on day 35 for histopathology. Responses were strongly time- and tissue-dependent, with the largest effects on day 21. In spleen, selected antimicrobials showed selective down-regulation of

Indexed as

Animal FeedAnti-Bacterial AgentsAnti-Infective AgentsChickensCytokinesTranscription, GeneticAnimalsCecumFemaleGene Expression RegulationIntestinal MucosaSpleenAnti-Bacterial AgentsAnti-Infective AgentsCytokinesantibiotic residuescytokinefeed cross-contaminationimmune modulationmucin

Identifiers

PMID42449964
PMCPMC13361393

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.