Evidence map›Paper›PMID 42449950›Full record

ArticleInternational journal of molecular sciences2026

ALK Knock-In Reporter Reveals APE1 as a Negative Regulator of

Matvey M Murashko, Ekaterina M Stasevich, Kirill V Korneev, Anna D Dorfman, Denis E Demin, Elvina A Prikhodko, Elina A Zheremyan, Aksinya N Uvarova, Anton M Schwartz, Dmitry V Kuprash

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Matvey M MurashkoCenter for Precision Genetic Technologies for Medicine, Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 32 Vavilova Street, Moscow 119991, Russia.ORCID 0000-0001-7235-5052
Ekaterina M StasevichCenter for Precision Genetic Technologies for Medicine, Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 32 Vavilova Street, Moscow 119991, Russia.ORCID 0000-0003-2150-9458
Kirill V KorneevCenter for Precision Genetic Technologies for Medicine, Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 32 Vavilova Street, Moscow 119991, Russia.ORCID 0000-0003-3570-8327
Anna D DorfmanEngelhardt Institute of Molecular Biology, Russian Academy of Sciences, 32 Vavilova Street, Moscow 119991, Russia.
Denis E DeminCenter for Precision Genetic Technologies for Medicine, Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 32 Vavilova Street, Moscow 119991, Russia.ORCID 0000-0002-5553-6588
Elvina A PrikhodkoEngelhardt Institute of Molecular Biology, Russian Academy of Sciences, 32 Vavilova Street, Moscow 119991, Russia.
Elina A ZheremyanCenter for Precision Genetic Technologies for Medicine, Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 32 Vavilova Street, Moscow 119991, Russia.ORCID 0000-0002-1230-6168
Aksinya N UvarovaCenter for Precision Genetic Technologies for Medicine, Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 32 Vavilova Street, Moscow 119991, Russia.ORCID 0000-0002-3168-6872
Anton M SchwartzDepartment of Human Biology, Faculty of Natural Sciences, University of Haifa, 199 Abba Khoushy Avenue, Mount Carmel, Haifa 3498838, Israel.
Dmitry V KuprashCenter for Precision Genetic Technologies for Medicine, Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 32 Vavilova Street, Moscow 119991, Russia.

Funding

Russian Science Foundation 25-14-00482
6 · The paper itself

Abstract

Chromosomal rearrangements that lead to the formation of oncogenic gene fusions, such as

Indexed as

Anaplastic Lymphoma KinaseDNA-(Apurinic or Apyrimidinic Site) LyaseOncogene Proteins, FusionA549 CellsCell Line, TumorDNA RepairGene Knock-In TechniquesGenes, ReporterHumansLuminescent ProteinsLung NeoplasmsAnaplastic Lymphoma KinaseAPEX1 protein, humanDNA-(Apurinic or Apyrimidinic Site) LyaseEML4-ALK fusion protein, humanLuminescent ProteinsOncogene Proteins, FusionALK rearrangementAPEX1/APE1chromosomal rearrangementCRISPR-Cas9DNA repairEML4-ALKfluorescent reporternon-small cell lung canceroncogenic gene fusion

Identifiers

PMID42449950
PMCPMC13362364

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.