Evidence map›Paper›PMID 42449850›Full record

ReviewDiagnostics (Basel, Switzerland)2026

Immunohistochemical Loss of MTAP as a Diagnostic and Prognostic Surrogate of

Serena Salzano, Rosario Caltabiano, Andrea Palicelli, Maurizio Zizzo, Massimiliano Fabozzi, Nektarios Koufopoulos, Ioannis Boutas, Gerardo Cazzato, Magda Zanelli, Giuseppe Broggi

Abstract readReview
In one paragraph

Review in Diagnostics (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Serena SalzanoDepartment of Medical and Surgical Sciences and Advanced Technologies "G.F. Ingrassia" Anatomic Pathology, University of Catania, 95123 Catania, Italy.ORCID 0009-0005-3669-8759
Rosario CaltabianoDepartment of Medical and Surgical Sciences and Advanced Technologies "G.F. Ingrassia" Anatomic Pathology, University of Catania, 95123 Catania, Italy.ORCID 0000-0001-8591-8010
Andrea PalicelliPathology Unit, Azienda USL-IRCCS di Reggio Emilia, 42123 Reggio Emilia, Italy.ORCID 0000-0003-2299-5160
Maurizio ZizzoSurgical Oncology Unit, Azienda USL-IRCCS di Reggio Emilia, 42122 Reggio Emilia, Italy.ORCID 0000-0001-9841-7856
Massimiliano FabozziSurgical Oncology Unit, Azienda USL-IRCCS di Reggio Emilia, 42122 Reggio Emilia, Italy.ORCID 0000-0001-5102-0210
Nektarios KoufopoulosSecond Department of Pathology, Medical School, National and Kapodistrian University of Athens, Attikon University Hospital, 12462 Athens, Greece.ORCID 0000-0001-9502-7916
Ioannis BoutasSecond Department of Pathology, Medical School, National and Kapodistrian University of Athens, Attikon University Hospital, 12462 Athens, Greece.
Gerardo CazzatoDepartment of Precision and Regenerative Medicine and Ionian Area (DiMePRe-J), Section of Molecular Pathology, University of Bari "Aldo Moro", 70121 Bari, Italy.ORCID 0000-0003-0325-4316
Magda ZanelliPathology Unit, Azienda USL-IRCCS di Reggio Emilia, 42123 Reggio Emilia, Italy.ORCID 0000-0002-8733-9933
Giuseppe BroggiDepartment of Medical and Surgical Sciences and Advanced Technologies "G.F. Ingrassia" Anatomic Pathology, University of Catania, 95123 Catania, Italy.ORCID 0000-0003-2576-6523

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Methylthioadenosine phosphorylase (MTAP) immunohistochemistry (IHC) has emerged as a valuable diagnostic, prognostic, and therapeutic biomarker in modern oncologic pathology, primarily serving as a surrogate for

Indexed as

9p21 chromosomal lossCDKN2A/B homozygous deletionMTAP immunohistochemistryPRMT5/MAT2A synthetic lethalityprognostic biomarker

Identifiers

PMID42449850
PMCPMC13360304

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.