Evidence map›Paper›PMID 42449630›Full record

ArticleCancers2026

Potent Anti-Glioblastoma Effects of Next-Generation MNK Inhibitors.

Candice Mazewski, Ricardo E Perez, Purav P Vagadia, Masha Kocherginsky, Gary E Schiltz, Frank Eckerdt, Leonidas C Platanias

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancers, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Candice MazewskiRobert H. Lurie Comprehensive Cancer Center of Northwestern University, Chicago, IL 60611, USA.ORCID 0000-0001-7030-0998
Ricardo E PerezRobert H. Lurie Comprehensive Cancer Center of Northwestern University, Chicago, IL 60611, USA.ORCID 0000-0001-5912-3505
Purav P VagadiaDepartment of Chemistry, Northwestern University, Evanston, IL 60208, USA.
Masha KocherginskyRobert H. Lurie Comprehensive Cancer Center of Northwestern University, Chicago, IL 60611, USA.
Gary E SchiltzRobert H. Lurie Comprehensive Cancer Center of Northwestern University, Chicago, IL 60611, USA.ORCID 0000-0003-4180-5051
Frank EckerdtRobert H. Lurie Comprehensive Cancer Center of Northwestern University, Chicago, IL 60611, USA.ORCID 0000-0001-6853-850X
Leonidas C PlataniasRobert H. Lurie Comprehensive Cancer Center of Northwestern University, Chicago, IL 60611, USA.

Funding

TRAINING PROGRAM IN SIGNAL TRANSDUCTION AND CANCERT32CA070085 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI LEONIDAS C. PLATANIAS · 1997 to 2026
$5.7M
Development of Novel MNK Inhibitors for Treating GlioblastomaR01NS113425 · NINDS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI PLATANIAS, LEONIDAS C., SCHILTZ, GARY E · 2019 to 2023
$2.5M
CSRD VA I01 CX000916Jesse Brown VA Medical Center I01-CX000916NCI NIH HHS T32 CA070085NINDS NIH HHS R01 NS113425NINDS NIH HHS R01-NS113425
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

apoptosisDNA methyltransferase (DNMT)glioblastoma (GBM)glioma stem cells (GSCs)invasionMAPK-interacting kinase (MNK)

Identifiers

PMID42449630
PMCPMC13360561

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.