Evidence map›Paper›PMID 42449626›Full record

ArticleCancers2026

Impact of Antibiotic Use in the Primary Treatment of Nasopharyngeal Carcinoma.

Bojie Chen, Whitney T Y Ngan, Timothy Shun Man Chu, Cherrie W K Ng, Eddy W Y Wong, Eric H L Lau, Samuel C C Cheng, Catherine P L Chan, Andy H K Chan, David Johnson and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancers, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Bojie ChenDepartment of Otorhinolaryngology, Head and Neck Surgery, The Chinese University of Hong Kong, Hong Kong SAR, China.
Whitney T Y NganDepartment of Otorhinolaryngology, Head and Neck Surgery, The Chinese University of Hong Kong, Hong Kong SAR, China.
Timothy Shun Man ChuDepartment of Otorhinolaryngology, Head and Neck Surgery, The Chinese University of Hong Kong, Hong Kong SAR, China.
Cherrie W K NgDepartment of Otorhinolaryngology, Head and Neck Surgery, The Chinese University of Hong Kong, Hong Kong SAR, China.
Eddy W Y WongDepartment of Otorhinolaryngology, Head and Neck Surgery, The Chinese University of Hong Kong, Hong Kong SAR, China.
Eric H L LauDepartment of Otorhinolaryngology, Head and Neck Surgery, The Chinese University of Hong Kong, Hong Kong SAR, China.
Samuel C C ChengDepartment of Otorhinolaryngology, Head and Neck Surgery, The Chinese University of Hong Kong, Hong Kong SAR, China.
Catherine P L ChanDepartment of Otorhinolaryngology, Head and Neck Surgery, The Chinese University of Hong Kong, Hong Kong SAR, China.ORCID 0000-0003-4755-2155
Andy H K ChanDepartment of Otorhinolaryngology, Head and Neck Surgery, The Chinese University of Hong Kong, Hong Kong SAR, China.
David JohnsonDepartment of Clinical Oncology, The Chinese University of Hong Kong, Hong Kong SAR, China.
Florence MokDepartment of Clinical Oncology, The Chinese University of Hong Kong, Hong Kong SAR, China.
Daisy LamDepartment of Clinical Oncology, The Chinese University of Hong Kong, Hong Kong SAR, China.
Kenneth C W WongDepartment of Clinical Oncology, The Chinese University of Hong Kong, Hong Kong SAR, China.ORCID 0000-0003-4995-0819
Brigette MaDepartment of Clinical Oncology, The Chinese University of Hong Kong, Hong Kong SAR, China.ORCID 0000-0003-4802-1102
Ka-Wai KwokDepartment of Mechanical Engineering, The University of Hong Kong, Hong Kong SAR, China.ORCID 0000-0003-1879-9730
Zigui ChenDepartment of Microbiology, The Chinese University of Hong Kong, Hong Kong SAR, China.ORCID 0000-0002-8577-1298
Jason Y K ChanDepartment of Otorhinolaryngology, Head and Neck Surgery, The Chinese University of Hong Kong, Hong Kong SAR, China.ORCID 0000-0002-9480-4637

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAntibiotics are commonly prescribed to patients with nasopharyngeal carcinoma (NPC) during chemoradiotherapy; however, peri-treatment antibiotic use may adversely affect patients' outcomes.

methodsA retrospective cohort study was conducted. The association between antibiotic use and patients' survival time was analyzed using Kaplan-Meier and Cox proportional hazards regression models.

resultsAmong 455 NPC patients, 42.0% received antibiotics around primary treatment. Patients who had an advanced tumor stage (

conclusionsIn NPC, antibiotic use around primary treatment was associated with poorer disease-specific survival. Further prospective studies are warranted to clarify the causality and underlying mechanisms.

Indexed as

antibioticschemoradiotherapyhead and neck cancernasopharyngeal carcinomasurvival

Identifiers

PMID42449626
PMCPMC13359527

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.