Evidence map›Paper›PMID 42449510›Full record

ArticleChemSusChem2026

DYNO-MILL-Assisted Mechanochemistry: Design of Experiments Optimization for Sustainable Synthesis of Pyrrolo[3,4-c]pyrazoles.

Roopam Pandey, Rémy Mariaux, Subhankar Bera, Khushi Verma, Ludovic Gremaud, Subhabrata Sen

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ChemSusChem, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Roopam PandeyDepartment of Chemistry, School of Natural Sciences, Shiv Nadar Institution of Eminence Deemed to be University, Dadri, Uttar Pradesh, India.
Rémy MariauxSchool of Engineering and Architecture of Fribourg, Department of Chemistry-Institute of Chemical Technology, HES-SO University of Applied Sciences and Arts Western Switzerland, Fribourg, Switzerland.
Subhankar BeraDepartment of Chemistry, School of Natural Sciences, Shiv Nadar Institution of Eminence Deemed to be University, Dadri, Uttar Pradesh, India.
Khushi VermaDepartment of Chemistry, School of Natural Sciences, Shiv Nadar Institution of Eminence Deemed to be University, Dadri, Uttar Pradesh, India.
Ludovic GremaudSchool of Engineering and Architecture of Fribourg, Department of Chemistry-Institute of Chemical Technology, HES-SO University of Applied Sciences and Arts Western Switzerland, Fribourg, Switzerland.
Subhabrata SenDepartment of Chemistry, School of Natural Sciences, Shiv Nadar Institution of Eminence Deemed to be University, Dadri, Uttar Pradesh, India.ORCID https://orcid.org/0000-0002-4608-5498

Funding

Shiv Nadar University
6 · The paper itself

Abstract

We report a sustainable DYNO-MILL-assisted mechanochemical synthesis of pyrrolo[3,4-c]pyrazoles via (3 + 2) cycloaddition between in situ generated nitrile imines and maleimides. Design of experiments (DoE) optimization identified key milling parameters, enabling efficient product formation in up to 78% yield under solvent-minimized, catalyst-free conditions. The method provides broad substrate scope, operational simplicity, and scalability. Comparative green metrics analysis highlights reduced waste generation and improved sustainability relative to conventional solution-phase approaches.

Indexed as

design of experiments (DoE)DYNO‐MILLgreen metricshorizontal bead millin situ nitrile imine

Identifiers

PMID42449510
PMCPMC13369779

What OpenQuestion holds

Textmetadata
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.