ArticleInternational journal of cancer2026
Bone Marrow Microenvironment Drives Mature Neutrophil to a CD83
Article in International journal of cancer, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Neutrophils are the most abundant immune cells in bone marrow (BM); their differentiation, maturation, and clearance are tightly regulated by the BM microenvironment. Multiple myeloma (MM) is a malignant plasma cell disorder that leads to multi-organ damage, including BM disruption, which may subsequently affect resident neutrophils. The present study was designed to systematically characterize BM neutrophils in MM, to advance the understanding of their potential biological roles in disease initiation and progression, and to identify potential neutrophil-based biomarkers of clinical relevance. Firstly, developmental profiling of BM neutrophils via cytomorphology and flow cytometry revealed a pronounced enrichment of mature neutrophils in MM patients. Furthermore, single-cell RNA sequencing (scRNA-seq) was utilized to characterize the transcriptional heterogeneity of BM neutrophils, with particular focus on the mature subsets. This analysis revealed a disease-specific subpopulation of CD83
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