ArticleInternational journal of retina and vitreous2026
Quantitative evaluation of pigment epithelial encapsulation using polarization-sensitive optical coherence tomography after anti-VEGF therapy for myopic choroidal neovascularization.
Article in International journal of retina and vitreous, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
purposeWe aimed to investigate the association between post-treatment changes in polarimetric entropy (PE), which is a noninvasive surrogate marker of structural heterogeneity associated with pigment epithelial remodeling and measured by polarization-sensitive optical coherence tomography (PS-OCT), and the need for multiple anti-vascular endothelial growth factor (VEGF)-injections in myopic choroidal neovascularization (mCNV).
methodsWe retrospectively analyzed 11 eyes that received intra-vitreal anti-VEGF injections for treatment-naïve mCNV. Based on treatment response during the first 3 months, eyes were categorized into the single-injection (n = 9) and multiple-injection (n = 2) groups. PS-OCT en face PE maps (6 × 6 mm) were obtained at baseline and 3 months after treatment, with the analysis area manually centered over the CNV using a 3-mm Early Treatment Diabetic Retinopathy Study (ETDRS) grid. PE values were extracted from the central 1-mm circle (CNV core) and surrounding 1-3-mm annulus (periphery), and the differences before and after treatment were calculated. Intergroup comparisons were conducted using Wilcoxon rank-sum test.
resultsPE within the CNV core increased after treatment (p = 0.0037). The multiple-injection group showed a greater PE increase than the single-injection group (p = 0.0347), although this finding should be interpreted cautiously given the small and imbalanced sample size. Exploratory analysis suggested a positive association between the magnitude of PE change in the CNV core and injection number during the 3-month period.
conclusionsHigh post-treatment entropy may reflect structural heterogeneity associated with pigment epithelial remodeling during the early healing phase. These findings suggest that PS-OCT entropy imaging may serve as a retrospective indicator of tissue response rather than a predictive biomarker in the present dataset. Given the very small and imbalanced sample size, the results should be interpreted as exploratory and hypothesis-generating.
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