Evidence map›Paper›PMID 42449405›Full record

ReviewJournal of ovarian research2026

Targeting the gut microbiome: an integrated probiotic and prebiotic strategy for polycystic ovary syndrome management.

Muchu Ni, Qin Wang, Tao Ye, Hongyan Lei, Yongzhou Wang, Yuan Yuan

Abstract readReview
PubMed Publisher
In one paragraph

Review in Journal of ovarian research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Muchu NiSchool of Integrated Traditional Chinese and Western Medicine, Southwest Medical University, Luzhou, 646000, Sichuan, China.
Qin WangSchool of Integrated Traditional Chinese and Western Medicine, Southwest Medical University, Luzhou, 646000, Sichuan, China.
Tao YeDepartment of Gynecology, Affiliated Traditional Chinese Medicine Hospital of Southwest Medical University, Luzhou, 646000, Sichuan, China.
Hongyan LeiDepartment of Gynecology, Affiliated Traditional Chinese Medicine Hospital of Southwest Medical University, Luzhou, 646000, Sichuan, China. lhywhb121@swmu.edu.cn.
Yongzhou WangDepartment of Gynecology, Affiliated Traditional Chinese Medicine Hospital of Southwest Medical University, Luzhou, 646000, Sichuan, China.
Yuan YuanDepartment of Gynecology, Affiliated Traditional Chinese Medicine Hospital of Southwest Medical University, Luzhou, 646000, Sichuan, China.

Funding

the Central Finance Traditional Chinese Medicine Inheritance and Development Subsidy Project (Subproject: Evidence-Based Capacity Enhancement Project of Traditional Chinese Medicine) 2100601the Luzhou Science and Technology Plan Project (No. 2022SYF37)the Science and Technology Project of the Sichuan Administration of Traditional Chinese Medicine (No. 2024MS210)
6 · The paper itself

Abstract

Polycystic ovary syndrome (PCOS) is a prevalent endocrine-metabolic disorder in which gut dysbiosis acts as a key environmental driver. This review synthesizes how probiotics and prebiotics remodel the gut ecosystem and ameliorate PCOS through multi-pathway mechanisms:restoring intestinal barrier function, modulating microbial metabolites (e.g., short-chain fatty acids(SCFAs), bile acids(BAs)), attenuating chronic inflammation, and regulating androgen metabolism. We further propose a novel "integrated microbiome‑centric management" framework, demonstrating how microbiota-targeted interventions synergize with dietary, pharmacological, and behavioral strategies to enable personalized, multi-modal PCOS care. This work provides a transformative perspective for translating gut microbiome science into clinical practice across disciplinary boundaries.

Indexed as

Gastrointestinal MicrobiomePolycystic Ovary SyndromePrebioticsProbioticsAnimalsDysbiosisFemaleHumansPrebioticsBile acidsGut dysbiosisIntegrated managementPolycystic ovary syndromeProbioticsShort-chain fatty acids

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.