Evidence map›Paper›PMID 42449393›Full record

ArticleJournal of medical case reports2026

Neuroleptic malignant syndrome precipitated by chlorpromazine: a case report.

Abdirahman Abdikadir Osman, Hussein Mahdi Ahmed, Mustafa Abdulrahman Ali, Abdisalam Ismail Hassan, Mustafa Yusuf Ahmed, Ahmed Muhammad Bashir, Mohamed Farah Osman Hidig, Marian Muse Osman

Abstract readCase Reports
PubMed Full text at PMC Publisher
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Article in Journal of medical case reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Abdirahman Abdikadir OsmanInternal Medicine Department, Royal Hospital, Mogadishu, Somalia.
Hussein Mahdi AhmedInternal Medicine Department, Royal Hospital, Mogadishu, Somalia.
Mustafa Abdulrahman AliPsychiatric Department, Habeb Psychiatric Hospital, Mogadishu, Somalia.
Abdisalam Ismail HassanFaculty of Medicine and Health Sciences, Jamhuriya University of Science and Technology, Mogadishu, Somalia. abdisalamsaza21@gmail.com.ORCID http://orcid.org/0009-0008-0596-1106
Mustafa Yusuf AhmedPublic Health Unit, Royal Hospital, Mogadishu, Somalia.
Ahmed Muhammad BashirResearch and Education Unit, Mogadishu Virtual Academy, Mogadishu, Somalia.
Mohamed Farah Osman HidigNeurology Department, Kalkal Hospital, Mogadishu, Somalia.
Marian Muse OsmanResearch Department, Somali National Institute of Health, Mogadishu, Somalia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundNeuroleptic malignant syndrome (NMS) is a rare but potentially fatal reaction to dopamine-blocking agents. Although most commonly associated with prolonged or high-dose antipsychotic use, it can also occur after a single therapeutic dose. CASE PRESENTATION: A 56-year-old Somali man developed acute NMS within hours of receiving a single intramuscular dose of chlorpromazine for agitation, presenting with hyperthermia, severe rigidity, altered mental status, autonomic instability, and markedly elevated creatine kinase levels. Alternative diagnoses were excluded, and prompt discontinuation of chlorpromazine with supportive care and bromocriptine resulted in rapid clinical and biochemical recovery.

conclusionThis case highlights that NMS may occur rapidly following a single lowtherapeutic dose of chlorpromazine. Early recognition and timely management are essential for favorable outcomes. To our knowledge, this is the first reported case of chlorpromazine-induced NMS from Somalia.

Indexed as

Antipsychotic AgentsChlorpromazineNeuroleptic Malignant SyndromePsychomotor AgitationHumansMaleMiddle AgedAntipsychotic AgentsChlorpromazineAntipsychotic adverse effectsCase reportChlorpromazineDopamine blockadeNeuroleptic malignant syndromeRhabdomyolysisSomalia

Identifiers

PMID42449393
PMCPMC13647888

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