Evidence map›Paper›PMID 42449260›Full record

ArticleBMC nephrology2026

Kidney histopathology associated with kidney function at 1 year post severe AKI related to ANCA-associated vasculitis.

Léonard Cauchy, Pierre Raynaud, Pascal Reboul, Sylvain Cariou, Sophie Renaud, Émilie Pambrun, Pedram Ahmadpoor, Laurent Daniel, Hélène Perrochia, Camille Dubart and 3 more

Abstract readMulticenter Study
PubMed Publisher
In one paragraph

Article in BMC nephrology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Léonard CauchyService de Néphrologie, dialyse et aphérèse, hôpital universitaire, CHU de Nîmes, Nîmes, France.
Pierre RaynaudService d'anatomie et cytologie pathologique, CH de Perpignan, Perpignan, France.
Pascal ReboulService de Néphrologie, dialyse et aphérèse, hôpital universitaire, CHU de Nîmes, Nîmes, France.
Sylvain CariouService de Néphrologie, dialyse et aphérèse, hôpital universitaire, CHU de Nîmes, Nîmes, France.
Sophie RenaudService de Néphrologie, dialyse et aphérèse, hôpital universitaire, CHU de Nîmes, Nîmes, France.
Émilie PambrunService de Néphrologie, dialyse et aphérèse, hôpital universitaire, CHU de Nîmes, Nîmes, France.
Pedram AhmadpoorService de Néphrologie, dialyse et aphérèse, hôpital universitaire, CHU de Nîmes, Nîmes, France.
Laurent DanielService d'anatomie et cytologie pathologie, AP-HM, Marseille, France.
Hélène PerrochiaService d'anatomie et cytologie pathologique, CHU de Montpellier, Montpellier, France.
Camille DubartNéphrologie, Hémodialyse et Soins intensifs métaboliques, CH de Perpignan, Perpignan, France.
Sébastien CanetNéphrologie, Hémodialyse et Soins intensifs métaboliques, CH de Perpignan, Perpignan, France.
Olivier Moranne *Service de Néphrologie, dialyse et aphérèse, hôpital universitaire, CHU de Nîmes, Nîmes, France.
Florian Garo *Service de Néphrologie, dialyse et aphérèse, hôpital universitaire, CHU de Nîmes, Nîmes, France. florian.garo@chu-nimes.fr.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionANCA-associated vasculitis is a rare autoimmune disease, and is particularly serious when the kidneys are involved. In addition to immunosuppressants, plasma exchanges are used to treat severe forms of vasculitis. The international guidelines recommend kidney biopsies for their diagnostic and prognostic roles. The Berden, ARRS (ANCA Renal Risk Score), and AKRiS (ANCA Kidney Risk Score) classifications show that certain histological lesions, such as interstitial fibrosis, tubular atrophy, and the percentage of normal glomeruli negatively impact kidney prognosis. The aim of this study was to evaluate the renal response of patients with severe forms of ANCA-associated vasculitis undergoing kidney biopsy and plasma exchanges, to identify the histological determinants favorable to kidney recovery.

methodThis was a retrospective multicenter study of 34 patients with ANCA-associated vasculitis with severe kidney involvement who were receiving plasma exchanges. The primary endpoint was death, the need for dialysis, or persistent kidney dysfunction (eGFR < 30 ml/min/1.73 m² for 3 months) at one year.

resultsAmong the 34 patients (56% men), 19 (55%) met the primary endpoint. The 15 patients with an eGFR > 30 ml/min/1.73 m² at one year were younger (60 vs. 70 years), mostly male (73% vs. 42%), and had higher CRP levels (107 vs. 32 mg/l). Histologically, this group had more normal glomeruli (25% vs. 11%), less glomerulosclerosis (15% vs. 22%), and more cellular and partial crescents.

conclusionPatients treated by therapeutic plasmapheresis with a better kidney prognosis at 1-year had more normal glomeruli, less glomerulosclerosis and was associated with higher CRP. These results could support the systematic use of kidney biopsies for severe forms of ANCA-associated vasculitis, to better adapt treatments.

Indexed as

Acute Kidney InjuryAnti-Neutrophil Cytoplasmic Antibody-Associated VasculitisKidneyAgedBiopsyFemaleGlomerular Filtration RateHumansMaleMiddle AgedPlasma ExchangeRetrospective StudiesSeverity of Illness IndexAcute kidney injuryANCA-associated vasculitisHistological prognosisKidney biopsyPlasmapheresis

Identifiers

PMID42449260

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.